Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Putative NF-kappa-B-activating protein 031N) (Virus-induced-signaling adapter) (VISA)
1_MPFAE 6_ DKTYK 11_ YICRN 16_ FSNFC 21_ NVDVV 26_ EILPY 31_ LPCLT 36_ ARDQD 41_ RLRAT 46_ CTLSG 51_ NRDTL 56_ WHLFN 61_ TLQRR 66_ PGWVE 71_ YFIAA 76_ LRGCE 81_ LVDLA 86_ DEVAS 91_ VYQSY 96_ QPRTS 101_ DRPPD 106_ PLEPP 111_ SLPAE 116_ RPGPP 121_ TPAAA 126_ HSIPY 131_ NSCRE 136_ KEPSY 141_ PMPVQ 146_ ETQAP 151_ ESPGE 156_ NSEQA 161_ LQTLS 166_ PRAIP 171_ RNPDG 176_ GPLES 181_ SSDLA 186_ ALSPL 191_ TSSGH 196_ QEQDT 201_ ELGST 206_ HTAGA 211_ TSSLT 216_ PSRGP 221_ VSPSV 226_ SFQPL 231_ ARSTP 236_ RASRL 241_ PGPTG 246_ SVVST 251_ GTSFS 256_ SSSPG 261_ LASAG 266_ AAEGK 271_ QGAES 276_ DQAEP 281_ IICSS 286_ GAEAP 291_ ANSLP 296_ SKVPT 301_ TLMPV 306_ NTVAL 311_ KVPAN 316_ PASVS 321_ TVPSK 326_ LPTSS 331_ KPPGA 336_ VPSNA 341_ LTNPA 346_ PSKLP 351_ INSTR 356_ AGMVP 361_ SKVPT 366_ SMVLT 371_ KVSAS 376_ TVPTD 381_ GSSRN 386_ EETPA 391_ APTPA 396_ GATGG 401_ SSAWL 406_ DSSSE 411_ NRGLG 416_ SELSK 421_ PGVLA 426_ SQVDS 431_ PFSGC 436_ FEDLA 441_ ISAST 446_ SLGMG 451_ PCHGP 456_ EENEY 461_ KSEGT 466_ FGIHV 471_ AENPS 476_ IQLLE 481_ GNPGP 486_ PADPD 491_ GGPRP 496_ QADRK 501_ FQERE 506_ VPCHR 511_ PSPGA 516_ LWLQV 521_ AVTGV 526_ LVVTL 531_LVVLY
1: Adapter required for innate immune defense against viruses (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20127681, PubMed:20451243, PubMed:21170385, PubMed:23087404, PubMed:27992402, PubMed:33139700, PubMed:37582970). Acts downstream of DHX33, RIGI and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFNB and RANTES (CCL5) (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20127681, PubMed:20451243, PubMed:20628368, PubMed:21170385, PubMed:23087404, PubMed:25636800, PubMed:27736772, PubMed:33110251). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state (PubMed:20451243). Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response (PubMed:20451243). May activate the same pathways following detection of extracellular dsRNA by TLR3 (PubMed:16153868). May protect cells from apoptosis (PubMed:16125763). Involved in NLRP3 inflammasome activation by mediating NLRP3 recruitment to mitochondria (PubMed:23582325)