Cytochrome P450 2U1 (Long-chain fatty acid omega-monooxygenase) (EC 1.14.14.80)
1_MSSPG 6_ PSQPP 11_ AEDPP 16_ WPARL 21_ LRAPL 26_ GLLRL 31_ DPSGG 36_ ALLLC 41_ GLVAL 46_ LGWSW 51_ LRRRR 56_ ARGIP 61_ PGPTP 66_ WPLVG 71_ NFGHV 76_ LLPPF 81_ LRRRS 86_ WLSSR 91_ TRAAG 96_ IDPSV 101_ IGPQV 106_ LLAHL 111_ ARVYG 116_ SIFSF 121_ FIGHY 126_ LVVVL 131_ SDFHS 136_ VREAL 141_ VQQAE 146_ VFSDR 151_ PRVPL 156_ ISIVT 161_ KEKGV 166_ VFAHY 171_ GPVWR 176_ QQRKF 181_ SHSTL 186_ RHFGL 191_ GKLSL 196_ EPKII 201_ EEFKY 206_ VKAEM 211_ QKHGE 216_ DPFCP 221_ FSIIS 226_ NAVSN 231_ IICSL 236_ CFGQR 241_ FDYTN 246_ SEFKK 251_ MLGFM 256_ SRGLE 261_ ICLNS 266_ QVLLV 271_ NICPW 276_ LYYLP 281_ FGPFK 286_ ELRQI 291_ EKDIT 296_ SFLKK 301_ IIKDH 306_ QESLD 311_ RENPQ 316_ DFIDM 321_ YLLHM 326_ EEERK 331_ NNSNS 336_ SFDEE 341_ YLFYI 346_ IGDLF 351_ IAGTD 356_ TTTNS 361_ LLWCL 366_ LYMSL 371_ NPDVQ 376_ EKVHE 381_ EIERV 386_ IGANR 391_ APSLT 396_ DKAQM 401_ PYTEA 406_ TIMEV 411_ QRLTV 416_ VVPLA 421_ IPHMT 426_ SENTV 431_ LQGYT 436_ IPKGT 441_ LILPN 446_ LWSVH 451_ RDPAI 456_ WEKPE 461_ DFYPN 466_ RFLDD 471_ QGQLI 476_ KKETF 481_ IPFGI 486_ GKRVC 491_ MGEQL 496_ AKMEL 501_ FLMFV 506_ SLMQS 511_ FAFAL 516_ PEDSK 521_ KPLLT 526_ GRFGL 531_ TLAPH 536_PFNIT
1: A cytochrome P450 monooxygenase involved in the metabolism of arachidonic acid and its conjugates (PubMed:14660610, PubMed:24563460). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:14660610, PubMed:24563460). Acts as an omega and omega-1 hydroxylase for arachidonic acid and possibly for other long chain fatty acids. May modulate the arachidonic acid signaling pathway and play a role in other fatty acid signaling processes (PubMed:14660610, PubMed:24563460). May down-regulate the biological activities of N-arachidonoyl-serotonin, an endocannabinoid that has anti-nociceptive effects through inhibition of fatty acid amide hydrolase FAAH, TRPV1 receptor and T-type calcium channels. Catalyzes C-2 oxidation of the indole ring of N-arachidonoyl-serotonin forming a less active product 2-oxo-N-arachidonoyl-serotonin (PubMed:24563460)