Gene name: COMMD6

Uniprot entry:

Q7Z4G1

Protein names:

COMM domain-containing protein 6

Protein sequence:

1_MEASS 6_ EPPLD 11_ AKSDV 16_ TNQLV 21_ DFQWK 26_ LGMAV 31_ SSDTC 36_ RSLKY 41_ PYVAV 46_ MLKVA 51_ DHSGQ 56_ VKTKC 61_ FEMTI 66_ PQFQN 71_ FYRQF 76_KEIAA

Protein annotations

Protein functions:

1: Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex (PubMed:37172566, PubMed:38459129). May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Down-regulates activation of NF-kappa-B (PubMed:15799966, PubMed:16573520). Inhibits TNF-induced NFKB1 activation (PubMed:15799966, PubMed:16573520)