Protein O-glucosyltransferase 3 (EC 2.4.1.-) (KDEL motif-containing protein 2) (Protein O-xylosyltransferase POGLUT3) (EC 2.4.2.-)
1_MRRLP 6_ RALLL 11_ QLRLA 16_ LLVAA 21_ GAPEV 26_ LVSAP 31_ RSLVW 36_ GPGLQ 41_ AAVVL 46_ PVRYF 51_ YLQAV 56_ NSEGQ 61_ NLTRS 66_ PAGET 71_ PFKVV 76_ VKSLS 81_ PKELV 86_ RIHVP 91_ KPLDR 96_ NDGTF 101_ LMRYR 106_ MYETV 111_ DEGLK 116_ IEVLY 121_ GDEHV 126_ AQSPY 131_ ILKGP 136_ VYHEY 141_ CECPE 146_ DPQAW 151_ QKTLS 156_ CPTKE 161_ PQIAK 166_ DFASF 171_ PSINL 176_ QQMLK 181_ EVPKR 186_ FGDER 191_ GAIVH 196_ YTILN 201_ NHVYR 206_ RSLGK 211_ YTDFK 216_ MFSDE 221_ ILLSL 226_ TRKVL 231_ LPDLE 236_ FYVNL 241_ GDWPL 246_ EHRKV 251_ NGTPS 256_ PIPII 261_ SWCGS 266_ LDSRD 271_ VVLPT 276_ YDITH 281_ SMLEA 286_ MRGVT 291_ NDLLS 296_ IQGNT 301_ GPSWI 306_ NKTER 311_ AFFRG 316_ RDSRE 321_ ERLQL 326_ VQLSK 331_ ENPQL 336_ LDAGI 341_ TGYFF 346_ FQEKE 351_ KELGK 356_ AKLMG 361_ FFDFF 366_ KYKYQ 371_ VNVDG 376_ TVAAY 381_ RYPYL 386_ MLGDS 391_ LVLKQ 396_ DSPYY 401_ EHFYM 406_ ALEPW 411_ KHYVP 416_ IKRNL 421_ SDLLE 426_ KVKWA 431_ KENDE 436_ EAKKI 441_ AKEGQ 446_ LMARD 451_ LLQPH 456_ RLYCY 461_ YYQVL 466_ QKYAE 471_ RQSSK 476_ PEVRD 481_ GMELV 486_ PQPED 491_ STAIC 496_ QCHRK 501_KPSRE
1: Protein glucosyltransferase that catalyzes the transfer of glucose from UDP-glucose to a serine residue within the consensus sequence peptide C-X-N-T-X-G-S-F-X-C (PubMed:30127001). Can also catalyze the transfer of xylose from UDP-xylose but less efficiently (PubMed:30127001). Specifically targets extracellular EGF repeats of proteins such as NOTCH1, NOTCH3, FBN1, FBN2 and LTBP1 (PubMed:30127001, PubMed:34411563). May regulate the transport of NOTCH1 and NOTCH3 to the plasma membrane and thereby the Notch signaling pathway (PubMed:30127001)