Protein FAM220A (STAT3-interacting protein as a repressor)
1_MRDRR 6_ GPLGT 11_ CLAQV 16_ QQAGG 21_ GDSDK 26_ LSCSL 31_ KKRMP 36_ EGPWP 41_ ADAPS 46_ WMNKP 51_ VVDGN 56_ SQSEA 61_ LSLEM 66_ RKDPS 71_ GAGLW 76_ LHSGG 81_ PVLPY 86_ VRESV 91_ RRNPA 96_ SAATP 101_ STAVG 106_ LFPAP 111_ TECFA 116_ RVSCS 121_ GVEAL 126_ GRRDW 131_ LGGGP 136_ RATDG 141_ HRGQC 146_ PKGEP 151_ RVSRL 156_ PRHQK 161_ VPEMG 166_ SFQDD 171_ PPSAF 176_ PKGLG 181_ SELEP 186_ ACLHS 191_ ILSAT 196_ LHVYP 201_ EVLLS 206_ EETKR 211_ IFLDR 216_ LKPMF 221_ SKQTI 226_ EFKKM 231_ LKSTS 236_ DGLQI 241_ TLGLL 246_ ALQPF 251_ELANT
1: Promotes dephosphorylation of transcriptional activator STAT3 by interacting with both STAT3 and protein phosphatase PTPN2. This promotes interaction of PTPN2 with STAT3 and mediates STAT3 dephosphorylation by PTPN2, leading to negative regulation of STAT3 transcriptional activator activity. May be required for spermiogenesis or sperm function