Transient receptor potential cation channel subfamily M member 1 (Long transient receptor potential channel 1) (LTrpC1) (Melastatin-1)
1_MKDSN 6_ RCCCG 11_ QFTNQ 16_ HIPPL 21_ PSATP 26_ SKNEE 31_ ESKQV 36_ ETQPE 41_ KWSVA 46_ KHTQS 51_ YPTDS 56_ YGVLE 61_ FQGGG 66_ YSNKA 71_ MYIRV 76_ SYDTK 81_ PDSLL 86_ HLMVK 91_ DWQLE 96_ LPKLL 101_ ISVHG 106_ GLQNF 111_ EMQPK 116_ LKQVF 121_ GKGLI 126_ KAAMT 131_ TGAWI 136_ FTGGV 141_ STGVI 146_ SHVGD 151_ ALKDH 156_ SSKSR 161_ GRVCA 166_ IGIAP 171_ WGIVE 176_ NKEDL 181_ VGKDV 186_ TRVYQ 191_ TMSNP 196_ LSKLS 201_ VLNNS 206_ HTHFI 211_ LADNG 216_ TLGKY 221_ GAEVK 226_ LRRLL 231_ EKHIS 236_ LQKIN 241_ TRLGQ 246_ GVPLV 251_ GLVVE 256_ GGPNV 261_ VSIVL 266_ EYLQE 271_ EPPIP 276_ VVICD 281_ GSGRA 286_ SDILS 291_ FAHKY 296_ CEEGG 301_ IINES 306_ LREQL 311_ LVTIQ 316_ KTFNY 321_ NKAQS 326_ HQLFA 331_ IIMEC 336_ MKKKE 341_ LVTVF 346_ RMGSE 351_ GQQDI 356_ EMAIL 361_ TALLK 366_ GTNVS 371_ APDQL 376_ SLALA 381_ WNRVD 386_ IARSQ 391_ IFVFG 396_ PHWPP 401_ LGSLA 406_ PPTDS 411_ KATEK 416_ EKKPP 421_ MATTK 426_ GGRGK 431_ GKGKK 436_ KGKVK 441_ EEVEE 446_ ETDPR 451_ KIELL 456_ NWVNA 461_ LEQAM 466_ LDALV 471_ LDRVD 476_ FVKLL 481_ IENGV 486_ NMQHF 491_ LTIPR 496_ LEELY 501_ NTRLG 506_ PPNTL 511_ HLLVR 516_ DVKKS 521_ NLPPD 526_ YHISL 531_ IDIGL 536_ VLEYL 541_ MGGAY 546_ RCNYT 551_ RKNFR 556_ TLYNN 561_ LFGPK 566_ RPKAL 571_ KLLGM 576_ EDDEP 581_ PAKGK 586_ KKKKK 591_ KKEEE 596_ IDIDV 601_ DDPAV 606_ SRFQY 611_ PFHEL 616_ MVWAV 621_ LMKRQ 626_ KMAVF 631_ LWQRG 636_ EESMA 641_ KALVA 646_ CKLYK 651_ AMAHE 656_ SSESD 661_ LVDDI 666_ SQDLD 671_ NNSKD 676_ FGQLA 681_ LELLD 686_ QSYKH 691_ DEQIA 696_ MKLLT 701_ YELKN 706_ WSNST 711_ CLKLA 716_ VAAKH 721_ RDFIA 726_ HTCSQ 731_ MLLTD 736_ MWMGR 741_ LRMRK 746_ NPGLK 751_ VIMGI 756_ LLPPT 761_ ILFLE 766_ FRTYD 771_ DFSYQ 776_ TSKEN 781_ EDGKE 786_ KEEEN 791_ TDANA 796_ DAGSR 801_ KGDEE 806_ NEHKK 811_ QRSIP 816_ IGTKI 821_ CEFYN 826_ APIVK 831_ FWFYT 836_ ISYLG 841_ YLLLF 846_ NYVIL 851_ VRMDG 856_ WPSLQ 861_ EWIVI 866_ SYIVS 871_ LALEK 876_ IREIL 881_ MSEPG 886_ KLSQK 891_ IKVWL 896_ QEYWN 901_ ITDLV 906_ AISTF 911_ MIGAI 916_ LRLQN 921_ QPYMG 926_ YGRVI 931_ YCVDI 936_ IFWYI 941_ RVLDI 946_ FGVNK 951_ YLGPY 956_ VMMIG 961_ KMMID 966_ MLYFV 971_ VIMLV 976_ VLMSF 981_ GVARQ 986_ AILHP 991_ EEKPS 996_ WKLAR 1001_ NIFYM 1006_ PYWMI 1011_ YGEVF 1016_ ADQID 1021_ LYAME 1026_ INPPC 1031_ GENLY 1036_ DEEGK 1041_ RLPPC 1046_ IPGAW 1051_ LTPAL 1056_ MACYL 1061_ LVANI 1066_ LLVNL 1071_ LIAVF 1076_ NNTFF 1081_ EVKSI 1086_ SNQVW 1091_ KFQRY 1096_ QLIMT 1101_ FHDRP 1106_ VLPPP 1111_ MIILS 1116_ HIYII 1121_ IMRLS 1126_ GRCRK 1131_ KREGD 1136_ QEERD 1141_ RGLKL 1146_ FLSDE 1151_ ELKRL 1156_ HEFEE 1161_ QCVQE 1166_ HFREK 1171_ EDEQQ 1176_ SSSDE 1181_ RIRVT 1186_ SERVE 1191_ NMSMR 1196_ LEEIN 1201_ ERETF 1206_ MKTSL 1211_ QTVDL 1216_ RLAQL 1221_ EELSN 1226_ RMVNA 1231_ LENLA 1236_ GIDRS 1241_ DLIQA 1246_ RSRAS 1251_ SECEA 1256_ TYLLR 1261_ QSSIN 1266_ SADGY 1271_ SLYRY 1276_ HFNGE 1281_ ELLFE 1286_ DTSLS 1291_ TSPGT 1296_ GVRKK 1301_ TCSFR 1306_ IKEEK 1311_ DVKTH 1316_ LVPEC 1321_ QNSLH 1326_ LSLGT 1331_ STSAT 1336_ PDGSH 1341_ LAVDD 1346_ LKNAE 1351_ ESKLG 1356_ PDIGI 1361_ SKEDD 1366_ ERQTD 1371_ SKKEE 1376_ TISPS 1381_ LNKTD 1386_ VIHGQ 1391_ DKSDV 1396_ QNTQL 1401_ TVETT 1406_ NIEGT 1411_ ISYPL 1416_ EETKI 1421_ TRYFP 1426_ DETIN 1431_ ACKTM 1436_ KSRSF 1441_ VYSRG 1446_ RKLVG 1451_ GVNQD 1456_ VEYSS 1461_ ITDQQ 1466_ LTTEW 1471_ QCQVQ 1476_ KITRS 1481_ HSTDI 1486_ PYIVS 1491_ EAAVQ 1496_ AEHKE 1501_ QFADM 1506_ QDEHH 1511_ VAEAI 1516_ PRIPR 1521_ LSLTI 1526_ TDRNG 1531_ MENLL 1536_ SVKPD 1541_ QTLGF 1546_ PSLRS 1551_ KSLHG 1556_ HPRNV 1561_ KSIQG 1566_ KLDRS 1571_ GHASS 1576_ VSSLV 1581_ IVSGM 1586_ TAEEK 1591_ KVKKE 1596_KASTE
1: Constitutively open nonselective divalent cation-conducting channels which mediate the influx of Ca(2+), Mg(2+), Mn(2+), Ba(2+), and Ni(2+) into the cytoplasm, leading to membrane depolarization (PubMed:11535825, PubMed:19436059, PubMed:21278253). Impermeable to zinc ions (PubMed:21278253). In addition, forms heteromultimeric ion channels with TRPM3 which are permeable for calcium and zinc ions (PubMed:21278253). Plays an essential role for the depolarizing photoresponse of retinal ON bipolar cells (PubMed:19878917, PubMed:19896109). In the dark, tonic release of glutamate activates the G-protein coupled receptor for glutamate, GRM6, its activation induces the release of G(o) protein and the beta-gamma G protein dimer. Both subunits can interact and inactivate the TRPM1 channel. A light onset, induces decrease in glutamate release and deactivation of GRM6 leading to channel opening and membrane depolarization (By similarity). May play a role in metastasis suppression (PubMed:9537257)