Hepatoma-derived growth factor-related protein 2 (HDGF-related protein 2) (HRP-2) (Hepatoma-derived growth factor 2) (HDGF-2)
1_MPHAF 6_ KPGDL 11_ VFAKM 16_ KGYPH 21_ WPARI 26_ DDIAD 31_ GAVKP 36_ PPNKY 41_ PIFFF 46_ GTHET 51_ AFLGP 56_ KDLFP 61_ YDKCK 66_ DKYGK 71_ PNKRK 76_ GFNEG 81_ LWEIQ 86_ NNPHA 91_ SYSAP 96_ PPVSS 101_ SDSEA 106_ PEANP 111_ ADGSD 116_ ADEDD 121_ EDRGV 126_ MAVTA 131_ VTATA 136_ ASDRM 141_ ESDSD 146_ SDKSS 151_ DNSGL 156_ KRKTP 161_ ALKMS 166_ VSKRA 171_ RKASS 176_ DLDQA 181_ SVSPS 186_ EEENS 191_ ESSSE 196_ SEKTS 201_ DQDFT 206_ PEKKA 211_ AVRAP 216_ RRGPL 221_ GGRKK 226_ KKAPS 231_ ASDSD 236_ SKADS 241_ DGAKP 246_ EPVAM 251_ ARSAS 256_ SSSSS 261_ SSSSD 266_ SDVSV 271_ KKPPR 276_ GRKPA 281_ EKPLP 286_ KPRGR 291_ KPKPE 296_ RPPSS 301_ SSSDS 306_ DSDEV 311_ DRISE 316_ WKRRD 321_ EARRR 326_ ELEAR 331_ RRREQ 336_ EEELR 341_ RLREQ 346_ EKEEK 351_ ERRRE 356_ RADRG 361_ EAERG 366_ SGGSS 371_ GDELR 376_ EDDEP 381_ VKKRG 386_ RKGRG 391_ RGPPS 396_ SSDSE 401_ PEAEL 406_ EREAK 411_ KSAKK 416_ PQSSS 421_ TEPAR 426_ KPGQK 431_ EKRVR 436_ PEEKQ 441_ QAKPV 446_ KVERT 451_ RKRSE 456_ GFSMD 461_ RKVEK 466_ KKEPS 471_ VEEKL 476_ QKLHS 481_ EIKFA 486_ LKVDS 491_ PDVKR 496_ CLNAL 501_ EELGT 506_ LQVTS 511_ QILQK 516_ NTDVV 521_ ATLKK 526_ IRRYK 531_ ANKDV 536_ MEKAA 541_ EVYTR 546_ LKSRV 551_ LGPKI 556_ EAVQK 561_ VNKAG 566_ MEKEK 571_ AEEKL 576_ AGEEL 581_ AGEEA 586_ PQEKA 591_ EDKPS 596_ TDLSA 601_ PVNGE 606_ ATSQK 611_ GESAE 616_ DKEHE 621_ EGRDS 626_ EEGPR 631_ CGSSE 636_ DLHDS 641_ VREGP 646_ DLDRP 651_ GSDRQ 656_ ERERA 661_ RGDSE 666_ALDEE
1: Acts as an epigenetic regulator of myogenesis in cooperation with DPF3a (isoform 2 of DPF3/BAF45C) (PubMed:32459350). Associates with the BAF complex via its interaction with DPF3a and HDGFL2-DPF3a activate myogenic genes by increasing chromatin accessibility through recruitment of SMARCA4/BRG1/BAF190A (ATPase subunit of the BAF complex) to myogenic gene promoters (PubMed:32459350). Promotes the repair of DNA double-strand breaks (DSBs) through the homologous recombination pathway by facilitating the recruitment of the DNA endonuclease RBBP8 to the DSBs (PubMed:26721387). Preferentially binds to chromatin regions marked by H3K9me3, H3K27me3 and H3K36me2 (PubMed:26721387, PubMed:32459350). Involved in cellular growth control, through the regulation of cyclin D1 expression (PubMed:25689719)