L-xylulose reductase (XR) (EC 1.1.1.10) (Carbonyl reductase II) (Dicarbonyl/L-xylulose reductase) (Kidney dicarbonyl reductase) (kiDCR) (Short chain dehydrogenase/reductase family 20C member 1) (Sperm surface protein P34H)
1_MELFL 6_ AGRRV 11_ LVTGA 16_ GKGIG 21_ RGTVQ 26_ ALHAT 31_ GARVV 36_ AVSRT 41_ QADLD 46_ SLVRE 51_ CPGIE 56_ PVCVD 61_ LGDWE 66_ ATERA 71_ LGSVG 76_ PVDLL 81_ VNNAA 86_ VALLQ 91_ PFLEV 96_ TKEAF 101_ DRSFE 106_ VNLRA 111_ VIQVS 116_ QIVAR 121_ GLIAR 126_ GVPGA 131_ IVNVS 136_ SQCSQ 141_ RAVTN 146_ HSVYC 151_ STKGA 156_ LDMLT 161_ KVMAL 166_ ELGPH 171_ KIRVN 176_ AVNPT 181_ VVMTS 186_ MGQAT 191_ WSDPH 196_ KAKTM 201_ LNRIP 206_ LGKFA 211_ EVEHV 216_ VNAIL 221_ FLLSD 226_ RSGMT 231_ TGSTL 236_PVEGG
1: Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules