BRCA1-associated protein (EC 2.3.2.27) (BRAP2) (Impedes mitogenic signal propagation) (IMP) (RING finger protein 52) (RING-type E3 ubiquitin transferase BRAP2) (Renal carcinoma antigen NY-REN-63)
1_MSVSL 6_ VVIRL 11_ ELAEH 16_ SPVPA 21_ GFGFS 26_ AAAGE 31_ MSDEE 36_ IKKTT 41_ LASAV 46_ ACLEG 51_ KSPGE 56_ KVAII 61_ HQHLG 66_ RREMT 71_ DVIIE 76_ TMKSN 81_ PDELK 86_ TTVEE 91_ RKSSE 96_ ASPTA 101_ QRSKD 106_ HSKEC 111_ INAAP 116_ DSPSK 121_ QLPDQ 126_ ISFFS 131_ GNPSV 136_ EIVHG 141_ IMHLY 146_ KTNKM 151_ TSLKE 156_ DVRRS 161_ AMLCI 166_ LTVPA 171_ AMTSH 176_ DLMKF 181_ VAPFN 186_ EVIEQ 191_ MKIIR 196_ DSTPN 201_ QYMVL 206_ IKFRA 211_ QADAD 216_ SFYMT 221_ CNGRQ 226_ FNSIE 231_ DDVCQ 236_ LVYVE 241_ RAEVL 246_ KSEDG 251_ ASLPV 256_ MDLTE 261_ LPKCT 266_ VCLER 271_ MDESV 276_ NGILT 281_ TLCNH 286_ SFHSQ 291_ CLQRW 296_ DDTTC 301_ PVCRY 306_ CQTPE 311_ PVEEN 316_ KCFEC 321_ GVQEN 326_ LWICL 331_ ICGHI 336_ GCGRY 341_ VSRHA 346_ YKHFE 351_ ETQHT 356_ YAMQL 361_ TNHRV 366_ WDYAG 371_ DNYVH 376_ RLVAS 381_ KTDGK 386_ IVQYE 391_ CEGDT 396_ CQEEK 401_ IDALQ 406_ LEYSY 411_ LLTSQ 416_ LESQR 421_ IYWEN 426_ KIVRI 431_ EKDTA 436_ EEINN 441_ MKTKF 446_ KETIE 451_ KCDNL 456_ EHKLN 461_ DLLKE 466_ KQSVE 471_ RKCTQ 476_ LNTKV 481_ AKLTN 486_ ELKEE 491_ QEMNK 496_ CLRAN 501_ QVLLQ 506_ NKLKE 511_ EERVL 516_ KETCD 521_ QKDLQ 526_ ITEIQ 531_ EQLRD 536_ VMFYL 541_ ETQQK 546_ INHLP 551_ AETRQ 556_ EIQEG 561_ QINIA 566_ MASAS 571_ SPASS 576_ GGSGK 581_ LPSRK 586_GRSKR
1: Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport