Microtubule organization protein AKNA (AT-hook-containing transcription factor)
1_MASSE 6_ TEIRW 11_ AEPGL 16_ GKGPQ 21_ RRRWA 26_ WAEDK 31_ RDVDR 36_ SSSQS 41_ WEEER 46_ LFPNA 51_ TSPEL 56_ LEDFR 61_ LAQQH 66_ LPPLE 71_ WDPHP 76_ QPDGH 81_ QDSES 86_ GETSG 91_ EEAEA 96_ EDVDS 101_ PASSH 106_ EPLAW 111_ LPQQG 116_ RQLDM 121_ TEEEP 126_ DGTLG 131_ SLEVE 136_ EAGES 141_ SSRLG 146_ YEAGL 151_ SLEGH 156_ GNTSP 161_ MALGH 166_ GQARG 171_ WVASG 176_ EQASG 181_ DKLSE 186_ HSEVN 191_ PSVEL 196_ SPARS 201_ WSSGT 206_ VSLDH 211_ PSDSL 216_ DSTWE 221_ GETDG 226_ PQPTA 231_ LAETL 236_ PEGPS 241_ HHLLS 246_ PDGRT 251_ GGSVA 256_ RATPM 261_ EFQDS 266_ SAPPA 271_ QSPQH 276_ ATDRW 281_ RRETT 286_ RFFCP 291_ QPKEH 296_ IWKQT 301_ KTSPK 306_ PLPSR 311_ FIGSI 316_ SPLNP 321_ QPRPT 326_ RQGRP 331_ LPRQG 336_ ATLAG 341_ RSSSN 346_ APKYG 351_ RGQLN 356_ YPLPD 361_ FSKVG 366_ PRVRF 371_ PKDES 376_ YRPPK 381_ SRSHN 386_ RKPQA 391_ PARPL 396_ IFKSP 401_ AEIVQ 406_ EVLLS 411_ SGEAA 416_ LAKDT 421_ PPAHP 426_ ITRVP 431_ QEFQT 436_ PEQAT 441_ ELVHQ 446_ LQEDY 451_ HRLLT 456_ KYAEA 461_ ENTID 466_ QLRLG 471_ AKVNL 476_ FSDPP 481_ QPNHS 486_ IHTGM 491_ VPQGT 496_ KVLSF 501_ TIPQP 506_ RSAEW 511_ WPGPA 516_ EDPQA 521_ SAASG 526_ WPSAR 531_ GDLSP 536_ SSLTS 541_ MPTLG 546_ WLPEN 551_ RDISE 556_ DQSSA 561_ EQTQA 566_ LASQA 571_ SQFLA 576_ KVESF 581_ ERLIQ 586_ AGRLM 591_ PQDQV 596_ KGFQR 601_ LKAAH 606_ AALEE 611_ EYLKA 616_ CREQH 621_ PAQPL 626_ AGSKG 631_ TPGRF 636_ DPRRE 641_ LEAEI 646_ YRLGS 651_ CLEEL 656_ KEHID 661_ QTQQE 666_ PEPPG 671_ SDSAL 676_ DSTPA 681_ LPCLH 686_ QPTHL 691_ PAPSG 696_ QAPMP 701_ AIKTS 706_ CPEPA 711_ TTTAA 716_ ASTGP 721_ CPLHV 726_ NVEVS 731_ SGNSE 736_ VEDRP 741_ QDPLA 746_ RLRHK 751_ ELQME 756_ QVYHG 761_ LMERY 766_ LSVKS 771_ LPEAM 776_ RMEEE 781_ EEGEE 786_ EEEEE 791_ GGGDS 796_ LEVDG 801_ VAATP 806_ GKAEA 811_ TRVLP 816_ RQCPV 821_ QAEKS 826_ HGAPL 831_ EEATE 836_ KMVSM 841_ KPPGF 846_ QASLA 851_ RDGHM 856_ SGLGK 861_ AEAAP 866_ PGPGV 871_ PPHPP 876_ GTKSA 881_ ASHQS 886_ SMTSL 891_ EGSGI 896_ SERLP 901_ QKPLH 906_ RGGGP 911_ HLEET 916_ WMASP 921_ ETDSG 926_ FVGSE 931_ TSRVS 936_ PLTQT 941_ PEHRL 946_ SHIST 951_ AGTLA 956_ QPFAA 961_ SVPRD 966_ GASYP 971_ KARGS 976_ LIPRR 981_ ATEPS 986_ TPRSQ 991_ AQRYL 996_ SSPSG 1001_ PLRQR 1006_ APNFS 1011_ LERTL 1016_ AAEMA 1021_ VPGSE 1026_ FEGHK 1031_ RISEQ 1036_ PLPNK 1041_ TISPP 1046_ PAPAP 1051_ AAAPL 1056_ PCGPT 1061_ ETIPS 1066_ FLLTR 1071_ AGRDQ 1076_ AICEL 1081_ QEEVS 1086_ RLRLR 1091_ LEDSL 1096_ HQPLQ 1101_ GSPTR 1106_ PASAF 1111_ DRPAR 1116_ TRGRP 1121_ ADSPA 1126_ TWGSH 1131_ YGSKS 1136_ TERLP 1141_ GEPRG 1146_ EEQIV 1151_ PPGRQ 1156_ RARSS 1161_ SVPRE 1166_ VLRLS 1171_ LSSES 1176_ ELPSL 1181_ PLFSE 1186_ KSKTT 1191_ KDSPQ 1196_ AARDG 1201_ KRGVG 1206_ SAGWP 1211_ DRVTF 1216_ RGQYT 1221_ GHEYH 1226_ VLSPK 1231_ AVPKG 1236_ NGTVS 1241_ CPHCR 1246_ PIRTQ 1251_ DAGGA 1256_ VTGDP 1261_ LGPPP 1266_ ADTLQ 1271_ CPLCG 1276_ QVGSP 1281_ PEADG 1286_ PGSAT 1291_ SGAEK 1296_ ATTRR 1301_ KASST 1306_ PSPKQ 1311_ RSKQA 1316_ GSSPR 1321_ PPPGL 1326_ WYLAT 1331_ APPAP 1336_ APPAF 1341_ AYISS 1346_ VPIMP 1351_ YPPAA 1356_ VYYAP 1361_ AGPTS 1366_ AQPAA 1371_ KWPPT 1376_ ASPPP 1381_ ARRHR 1386_ HSIQL 1391_ DLGDL 1396_ EELNK 1401_ ALSRA 1406_ VQAAE 1411_ SVRST 1416_ TRQMR 1421_ SSLSA 1426_ DLRQA 1431_HSLRG
1: Centrosomal protein that plays a key role in cell delamination by regulating microtubule organization (By similarity). Required for the delamination and retention of neural stem cells from the subventricular zone during neurogenesis (By similarity). Also regulates the epithelial-to-mesenchymal transition in other epithelial cells (By similarity). Acts by increasing centrosomal microtubule nucleation and recruiting nucleation factors and minus-end stabilizers, thereby destabilizing microtubules at the adherens junctions and mediating constriction of the apical endfoot (By similarity). In addition, may also act as a transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development (PubMed:11268217). Binds to A/T-rich promoters (PubMed:11268217). It is unclear how it can both act as a microtubule organizer and as a transcription factor; additional evidences are required to reconcile these two apparently contradictory functions (Probable)