Chemokine-like protein TAFA-5
1_MAPSP 6_ RTGSR 11_ QDATA 16_ LPSMS 21_ STFWA 26_ FMILA 31_ SLLIA 36_ YCSQL 41_ AAGTC 46_ EIVTL 51_ DRDSS 56_ QPRRT 61_ IARQT 66_ ARCAC 71_ RKGQI 76_ AGTTR 81_ ARPAC 86_ VDARI 91_ IKTKQ 96_ WCDML 101_ PCLEG 106_ EGCDL 111_ LINRS 116_ GWTCT 121_ QPGGR 126_IKTTT
1: Acts as a chemokine-like protein by regulating cell proliferation and migration through activation of G protein-coupled receptors (GPCRs), such as S1PR2 and FPR2 (By similarity). Stimulates chemotactic migration of macrophages mediated by the MAPK3/ERK1 and AKT1 pathway (By similarity). Blocks TNFSF11/RANKL-induced osteoclast formation from macrophages by inhibiting up-regulation of osteoclast fusogenic and differentiation genes (By similarity). Stimulation of macrophage migration and inhibition of osteoclast formation is mediated via GPCR FPR2 (By similarity). Acts as an adipokine by negatively regulating vascular smooth muscle cell (VSMC) proliferation and migration in response to platelet-derived growth factor stimulation via GPCR S1PR2 and G protein GNA12/GNA13-transmitted RHOA signaling (By similarity). Inhibits injury-induced cell proliferation and neointima formation in the femoral arteries (By similarity)