DNA polymerase nu (EC 2.7.7.7)
1_MENYE 6_ ALVGF 11_ DLCNT 16_ PLSSV 21_ AQKIM 26_ SAMHS 31_ GDLVD 36_ SKTWG 41_ KSTET 46_ MEVIN 51_ KSSVK 56_ YSVQL 61_ EDRKT 66_ QSPEK 71_ KDLKS 76_ LRSQT 81_ SRGSA 86_ KLSPQ 91_ SFSVR 96_ LTDQL 101_ SADQK 106_ QKSIS 111_ SLTLS 116_ SCLIP 121_ QYNQE 126_ ASVLQ 131_ KKGHK 136_ RKHFL 141_ MENIN 146_ NENKG 151_ SINLK 156_ RKHIT 161_ YNNLS 166_ EKTSK 171_ QMALE 176_ EDTDD 181_ AEGYL 186_ NSGNS 191_ GALKK 196_ HFCDI 201_ RHLDD 206_ WAKSQ 211_ LIEML 216_ KQAAA 221_ LVITV 226_ MYTDG 231_ STQLG 236_ ADQTP 241_ VSSVR 246_ GIVVL 251_ VKRQA 256_ EGGHG 261_ CPDAP 266_ ACGPV 271_ LEGFV 276_ SDDPC 281_ IYIQI 286_ EHSAI 291_ WDQEQ 296_ EAHQQ 301_ FARNV 306_ LFQTM 311_ KCKCP 316_ VICFN 321_ AKDFV 326_ RIVLQ 331_ FFGND 336_ GSWKH 341_ VADFI 346_ GLDPR 351_ IAAWL 356_ IDPSD 361_ ATPSF 366_ EDLVE 371_ KYCEK 376_ SITVK 381_ VNSTY 386_ GNSSR 391_ NIVNQ 396_ NVREN 401_ LKTLY 406_ RLTMD 411_ LCSKL 416_ KDYGL 421_ WQLFR 426_ TLELP 431_ LIPIL 436_ AVMES 441_ HAIQV 446_ NKEEM 451_ EKTSA 456_ LLGAR 461_ LKELE 466_ QEAHF 471_ VAGER 476_ FLITS 481_ NNQLR 486_ EILFG 491_ KLKLH 496_ LLSQR 501_ NSLPR 506_ TGLQK 511_ YPSTS 516_ EAVLN 521_ ALRDL 526_ HPLPK 531_ IILEY 536_ RQVHK 541_ IKSTF 546_ VDGLL 551_ ACMKK 556_ GSISS 561_ TWNQT 566_ GTVTG 571_ RLSAK 576_ HPNIQ 581_ GISKH 586_ PIQIT 591_ TPKNF 596_ KGKED 601_ KILTI 606_ SPRAM 611_ FVSSK 616_ GHTFL 621_ AADFS 626_ QIELR 631_ ILTHL 636_ SGDPE 641_ LLKLF 646_ QESER 651_ DDVFS 656_ TLTSQ 661_ WKDVP 666_ VEQVT 671_ HADRE 676_ QTKKV 681_ VYAVV 686_ YGAGK 691_ ERLAA 696_ CLGVP 701_ IQEAA 706_ QFLES 711_ FLQKY 716_ KKIKD 721_ FARAA 726_ IAQCH 731_ QTGCV 736_ VSIMG 741_ RRRPL 746_ PRIHA 751_ HDQQL 756_ RAQAE 761_ RQAVN 766_ FVVQG 771_ SAADL 776_ CKLAM 781_ IHVFT 786_ AVAAS 791_ HTLTA 796_ RLVAQ 801_ IHDEL 806_ LFEVE 811_ DPQIP 816_ ECAAL 821_ VRRTM 826_ ESLEQ 831_ VQALE 836_ LQLQV 841_ PLKVS 846_ LSAGR 851_ SWGHL 856_ VPLQE 861_ AWGPP 866_ PGPCR 871_ TESPS 876_ NSLAA 881_ PGSPA 886_ STQPP 891_PLHFS
1: DNA polymerase with very low fidelity that catalyzes considerable misincorporation by inserting dTTP opposite a G template, and dGTP opposite a T template (PubMed:16787914, PubMed:17118716). Is the least accurate of the DNA polymerase A family (i.e. POLG, POLN and POLQ) (PubMed:17118716). Can perform accurate translesion DNA synthesis (TLS) past a 5S-thymine glycol. Can perform efficient strand displacement past a nick or a gap and gives rise to an amount of product similar to that on non-damaged template. Has no exonuclease activity (PubMed:16787914). Error-prone DNA polymerase that preferentially misincorporates dT regardless of template sequence (PubMed:25775266). May play a role in TLS during interstrand cross-link (ICL) repair (PubMed:19908865). May be involved in TLS when genomic replication is blocked by extremely large major groove DNA lesions. May function in the bypass of some DNA-protein and DNA-DNA cross-links. May have a role in cellular tolerance to DNA cross-linking agents (PubMed:20102227). Involved in the repair of DNA cross-links and double-strand break (DSB) resistance. Participates in FANCD2-mediated repair. Forms a complex with HELQ helicase that participates in homologous recombination (HR) repair and is essential for cellular protection against DNA cross-links (PubMed:19995904)