RNA 5'-monophosphate methyltransferase (EC 2.1.1.-) (BCDIN3 domain-containing protein)
1_MAVPT 6_ ELDGG 11_ SVKET 16_ AAEEE 21_ SRVLA 26_ PGAAP 31_ FGNFP 36_ HYSRF 41_ HPPEQ 46_ RLRLL 51_ PPELL 56_ RQLFP 61_ ESPEN 66_ GPILG 71_ LDVGC 76_ NSGDL 81_ SVALY 86_ KHFLS 91_ LPDGE 96_ TCSDA 101_ SREFR 106_ LLCCD 111_ IDPVL 116_ VKRAE 121_ KECPF 126_ PDALT 131_ FITLD 136_ FMNQR 141_ TRKVL 146_ LSSFL 151_ SQFGR 156_ SVFDI 161_ GFCMS 166_ ITMWI 171_ HLNHG 176_ DHGLW 181_ EFLAH 186_ LSSLC 191_ HYLLV 196_ EPQPW 201_ KCYRA 206_ AARRL 211_ RKLGL 216_ HDFDH 221_ FHSLA 226_ IRGDM 231_ PNQIV 236_ QILTQ 241_ DHGME 246_ LICCF 251_ GNTSW 256_ DRSLL 261_ LFRAK 266_ QTIET 271_ HPIPE 276_ SLIEK 281_ GKEKN 286_RLSFQ
1: O-methyltransferase that specifically monomethylates 5'-monophosphate of cytoplasmic histidyl tRNA (tRNA(His)), acting as a capping enzyme by protecting tRNA(His) from cleavage by DICER1 (PubMed:28119416, PubMed:31329584, PubMed:31919512). Also able, with less efficiently, to methylate the 5' monophosphate of a subset of pre-miRNAs, acting as a negative regulator of miRNA processing (PubMed:23063121, PubMed:28119416). The 5' monophosphate of pre-miRNAs is recognized by DICER1 and is required for pre-miRNAs processing: methylation at this position reduces the processing of pre-miRNAs by DICER1 (PubMed:23063121). Was also reported to mediate dimethylation of pre-miR-145; however dimethylation cannot be reproduced by another group which observes a monomethylation of pre-miR-145 (PubMed:23063121, PubMed:28119416)