Bone morphogenetic protein 8A (BMP-8A)
1_MAARP 6_ GPLWL 11_ LGLTL 16_ CALGG 21_ GGPGL 26_ RPPPG 31_ CPQRR 36_ LGARE 41_ RRDVQ 46_ REILA 51_ VLGLP 56_ GRPRP 61_ RAPPA 66_ ASRLP 71_ ASAPL 76_ FMLDL 81_ YHAMA 86_ GDDDE 91_ DGAPA 96_ EQRLG 101_ RADLV 106_ MSFVN 111_ MVERD 116_ RALGH 121_ QEPHW 126_ KEFRF 131_ DLTQI 136_ PAGEA 141_ VTAAE 146_ FRIYK 151_ VPSIH 156_ LLNRT 161_ LHVSM 166_ FQVVQ 171_ EQSNR 176_ ESDLF 181_ FLDLQ 186_ TLRAG 191_ DEGWL 196_ VLDVT 201_ AASDC 206_ WLLKR 211_ HKDLG 216_ LRLYV 221_ ETEDG 226_ HSVDP 231_ GLAGL 236_ LGQRA 241_ PRSQQ 246_ PFVVT 251_ FFRAS 256_ PSPIR 261_ TPRAV 266_ RPLRR 271_ RQPKK 276_ SNELP 281_ QANRL 286_ PGIFD 291_ DVRGS 296_ HGRQV 301_ CRRHE 306_ LYVSF 311_ QDLGW 316_ LDWVI 321_ APQGY 326_ SAYYC 331_ EGECS 336_ FPLDS 341_ CMNAT 346_ NHAIL 351_ QSLVH 356_ LMKPN 361_ AVPKA 366_ CCAPT 371_ KLSAT 376_ SVLYY 381_ DSSNN 386_ VILRK 391_ HRNMV 396_VKACG
1: Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis (By similarity). Signaling protein involved in regulation of thermogenesis and energy balance. Proposed to increase the peripheral response of brown adipose tissue (BAT) to adrenergic stimulation while acting centrally in the hypothalamus to increase sympathetic output to BAT
2: Growth factor of the TGF-beta superfamily that plays important role in various biological processes, including spermatogenesis, osteogenesis, steroidogenesis as well as regulation of energy balance (PubMed:22579288, PubMed:31940275). Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2 (PubMed:31940275). Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. In addition, activates the SMAD2/3 pathway (PubMed:31940275)