Neuroepithelial cell-transforming gene 1 protein (Proto-oncogene p65 Net1) (Rho guanine nucleotide exchange factor 8)
1_MEPEL 6_ AAQKQ 11_ PRPRR 16_ RSRRA 21_ SGLST 26_ EGATG 31_ PSADT 36_ SGSEL 41_ DGRCS 46_ LRRGS 51_ SFTFL 56_ TPGPN 61_ WDFTL 66_ KRKRR 71_ EKDDD 76_ VVSLS 81_ SLDLK 86_ EPSNK 91_ RVRPL 96_ ARVTS 101_ LANLI 106_ SPVRN 111_ GAVRR 116_ FGQTI 121_ QSFTL 126_ RGDHR 131_ SPASA 136_ QKFSS 141_ RSTVP 146_ TPAKR 151_ RSSAL 156_ WSEML 161_ DITMK 166_ ESLTT 171_ REIRR 176_ QEAIY 181_ EMSRG 186_ EQDLI 191_ EDLKL 196_ ARKAY 201_ HDPML 206_ KLSIM 211_ SEEEL 216_ THIFG 221_ DLDSY 226_ IPLHE 231_ DLLTR 236_ IGEAT 241_ KPDGT 246_ VEQIG 251_ HILVS 256_ WLPRL 261_ NAYRG 266_ YCSNQ 271_ LAAKA 276_ LLDQK 281_ KQDPR 286_ VQDFL 291_ QRCLE 296_ SPFSR 301_ KLDLW 306_ SFLDI 311_ PRSRL 316_ VKYPL 321_ LLKEI 326_ LKHTP 331_ KEHPD 336_ VQLLE 341_ DAILI 346_ IQGVL 351_ SDINL 356_ KKGES 361_ ECQYY 366_ IDKLE 371_ YLDEK 376_ QRDPR 381_ IEASK 386_ VLLCH 391_ GELRS 396_ KSGHK 401_ LYIFL 406_ FQDIL 411_ VLTRP 416_ VTRNE 421_ RHSYQ 426_ VYRQP 431_ IPVQE 436_ LVLED 441_ LQDGD 446_ VRMGG 451_ SFRGA 456_ FSNSE 461_ KAKNI 466_ FRIRF 471_ HDPSP 476_ AQSHT 481_ LQAND 486_ VFHKQ 491_ QWFNC 496_ IRAAI 501_ APFQS 506_ AGSPP 511_ ELQGL 516_ PELHE 521_ ECEGN 526_ HPSAR 531_ KLTAQ 536_ RRAST 541_ VSSVT 546_ QVEVD 551_ ENAYR 556_ CGSGM 561_ QMAED 566_ SKSLK 571_ THQTQ 576_ PGIRR 581_ ARDKA 586_ LSGGK 591_RKETL
1: Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death