Sprouty-related, EVH1 domain-containing protein 2 (Spred-2)
1_MTEET 6_ HPDDD 11_ SYIVR 16_ VKAVV 21_ MTRDD 26_ SSGGW 31_ FPQEG 36_ GGISR 41_ VGVCK 46_ VMHPE 51_ GNGRS 56_ GFLIH 61_ GERQK 66_ DKLVV 71_ LECYV 76_ RKDLV 81_ YTKAN 86_ PTFHH 91_ WKVDN 96_ RKFGL 101_ TFQSP 106_ ADARA 111_ FDRGV 116_ RKAIE 121_ DLIEG 126_ STTSS 131_ STIHN 136_ EAELG 141_ DDDVF 146_ TTATD 151_ SSSNS 156_ SQKRE 161_ QPTRT 166_ ISSPT 171_ SCEHR 176_ RIYTL 181_ GHLHD 186_ SYPTD 191_ HYHLD 196_ QPMPR 201_ PYRQV 206_ SFPDD 211_ DEEIV 216_ RINPR 221_ EKIWM 226_ TGYED 231_ YRHAP 236_ VRGKY 241_ PDPSE 246_ DADSS 251_ YVRFA 256_ KGEVP 261_ KHDYN 266_ YPYVD 271_ SSDFG 276_ LGEDP 281_ KGRGG 286_ SVIKT 291_ QPSRG 296_ KSRRR 301_ KEDGE 306_ RSRCV 311_ YCRDM 316_ FNHEE 321_ NRRGH 326_ CQDAP 331_ DSVRT 336_ CIRRV 341_ SCMWC 346_ ADSML 351_ YHCMS 356_ DPEGD 361_ YTDPC 366_ SCDTS 371_ DEKFC 376_ LRWMA 381_ LIALS 386_ FLAPC 391_ MCCYL 396_ PLRAC 401_ YHCGV 406_ MCRCC 411_GGKHK
1: Negatively regulates Ras signaling pathways and downstream activation of MAP kinases (PubMed:15683364, PubMed:34626534). Recruits and translocates NF1 to the cell membrane, thereby enabling NF1-dependent hydrolysis of active GTP-bound Ras to inactive GDP-bound Ras (PubMed:34626534). Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity)