Sprouty-related, EVH1 domain-containing protein 1 (Spred-1) (hSpred1)
1_MSEET 6_ ATSDN 11_ DNSYA 16_ RVRAV 21_ VMTRD 26_ DSSGG 31_ WLPLG 36_ GSGLS 41_ SVTVF 46_ KVPHQ 51_ EENGC 56_ ADFFI 61_ RGERL 66_ RDKMV 71_ VLECM 76_ LKKDL 81_ IYNKV 86_ TPTFH 91_ HWKID 96_ DKKFG 101_ LTFQS 106_ PADAR 111_ AFDRG 116_ IRRAI 121_ EDISQ 126_ GCPES 131_ KNEAE 136_ GADDL 141_ QANEE 146_ DSSSS 151_ LVKDH 156_ LFQQE 161_ TVVTS 166_ EPYRS 171_ SNIRP 176_ SPFED 181_ LNARR 186_ VYMQS 191_ QANQI 196_ TFGQP 201_ GLDIQ 206_ SRSME 211_ YVQRQ 216_ ISKEC 221_ GSLKS 226_ QNRVP 231_ LKSIR 236_ HVSFQ 241_ DEDEI 246_ VRINP 251_ RDILI 256_ RRYAD 261_ YRHPD 266_ MWKND 271_ LERDD 276_ ADSSI 281_ QFSKP 286_ DSKKS 291_ DYLYS 296_ CGDET 301_ KLSSP 306_ KDSVV 311_ FKTQP 316_ SSLKI 321_ KKSKR 326_ RKEDG 331_ ERSRC 336_ VYCQE 341_ RFNHE 346_ ENVRG 351_ KCQDA 356_ PDPIK 361_ RCIYQ 366_ VSCML 371_ CAESM 376_ LYHCM 381_ SDSEG 386_ DFSDP 391_ CSCDT 396_ SDDKF 401_ CLRWL 406_ ALVAL 411_ SFIVP 416_ CMCCY 421_ VPLRM 426_ CHRCG 431_ EACGC 436_CGGKH
1: Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase (By similarity). Negatively regulates hematopoiesis of bone marrow (By similarity). Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Attenuates actin stress fiber formation via inhibition of TESK1-mediated phosphorylation of cofilin (PubMed:18216281). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity)