B- and T-lymphocyte attenuator (B- and T-lymphocyte-associated protein) (CD antigen CD272)
1_MKTLP 6_ AMLGT 11_ GKLFW 16_ VFFLI 21_ PYLDI 26_ WNIHG 31_ KESCD 36_ VQLYI 41_ KRQSE 46_ HSILA 51_ GDPFE 56_ LECPV 61_ KYCAN 66_ RPHVT 71_ WCKLN 76_ GTTCV 81_ KLEDR 86_ QTSWK 91_ EEKNI 96_ SFFIL 101_ HFEPV 106_ LPNDN 111_ GSYRC 116_ SANFQ 121_ SNLIE 126_ SHSTT 131_ LYVTD 136_ VKSAS 141_ ERPSK 146_ DEMAS 151_ RPWLL 156_ YRLLP 161_ LGGLP 166_ LLITT 171_ CFCLF 176_ CCLRR 181_ HQGKQ 186_ NELSD 191_ TAGRE 196_ INLVD 201_ AHLKS 206_ EQTEA 211_ STRQN 216_ SQVLL 221_ SETGI 226_ YDNDP 231_ DLCFR 236_ MQEGS 241_ EVYSN 246_ PCLEE 251_ NKPGI 256_ VYASL 261_ NHSVI 266_ GPNSR 271_ LARNV 276_ KEAPT 281_EYASI
1: Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:12796776, PubMed:14652006, PubMed:15568026, PubMed:18193050). May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14 (PubMed:19915044). In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells (PubMed:19915044)