SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho GTPase-activating protein 13)
1_MSTPS 6_ RFKKD 11_ KEIIA 16_ EYESQ 21_ VKEIR 26_ AQLVE 31_ QQKCL 36_ EQQTE 41_ MRVQL 46_ LQDLQ 51_ DFFRK 56_ KAEIE 61_ TEYSR 66_ NLEKL 71_ AERFM 76_ AKTRS 81_ TKDHQ 86_ QYKKD 91_ QNLLS 96_ PVNCW 101_ YLLLN 106_ QVRRE 111_ SKDHA 116_ TLSDI 121_ YLNNV 126_ IMRFM 131_ QISED 136_ STRMF 141_ KKSKE 146_ IAFQL 151_ HEDLM 156_ KVLNE 161_ LYTVM 166_ KTYHM 171_ YHAES 176_ ISAES 181_ KLKEA 186_ EKQEE 191_ KQIGR 196_ SGDPV 201_ FHIRL 206_ EERHQ 211_ RRSSV 216_ KKIEK 221_ MKEKR 226_ QAKYS 231_ ENKLK 236_ SIKAR 241_ NEYLL 246_ TLEAT 251_ NASVF 256_ KYYIH 261_ DLSDL 266_ IDCCD 271_ LGYHA 276_ SLNRA 281_ LRTYL 286_ SAEYN 291_ LETSR 296_ HEGLD 301_ IIENA 306_ VDNLE 311_ PRSDK 316_ QRFME 321_ MYPAA 326_ FCPPM 331_ KFEFQ 336_ SHMGD 341_ EVCQV 346_ SAQQP 351_ VQAEL 356_ MLRYQ 361_ QLQSR 366_ LATLK 371_ IENEE 376_ VKKTT 381_ EATLQ 386_ TIQDM 391_ VTIED 396_ YDVSE 401_ CFQHS 406_ RSTES 411_ VKSTV 416_ SETYL 421_ SKPSI 426_ AKRRA 431_ NQQET 436_ EQFYF 441_ MKLRE 446_ YLEGS 451_ NLITK 456_ LQAKH 461_ DLLQR 466_ TLGEG 471_ HRAEY 476_ MTTRP 481_ PNVPP 486_ KPQKH 491_ RKSRP 496_ RSQYN 501_ TKLFN 506_ GDLET 511_ FVKDS 516_ GQVIP 521_ LIVES 526_ CIRFI 531_ NLYGL 536_ QHQGI 541_ FRVSG 546_ SQVEV 551_ NDIKN 556_ SFERG 561_ ENPLA 566_ DDQSN 571_ HDINS 576_ VAGVL 581_ KLYFR 586_ GLENP 591_ LFPKE 596_ RFNDL 601_ ISCIR 606_ IDNLY 611_ ERALH 616_ IRKLL 621_ LTLPR 626_ SVLIV 631_ MRYLF 636_ AFLNH 641_ LSQYS 646_ DENMM 651_ DPYNL 656_ AICFG 661_ PTLMP 666_ VPEIQ 671_ DQVSC 676_ QAHVN 681_ EIIKT 686_ IIIHH 691_ ETIFP 696_ DAKEL 701_ DGPVY 706_ EKCMA 711_ GDDYC 716_ DSPYS 721_ EHGTL 726_ EEVDQ 731_ DAGTE 736_ PHTSE 741_ DECEP 746_ IEAIA 751_ KFDYV 756_ GRSAR 761_ ELSFK 766_ KGASL 771_ LLYHR 776_ ASEDW 781_ WEGRH 786_ NGIDG 791_ LVPHQ 796_ YIVVQ 801_ DMDDT 806_ FSDTL 811_ SQKAD 816_ SEASS 821_ GPVTE 826_ DKSSS 831_ KDMNS 836_ PTDRH 841_ PDGYL 846_ ARQRK 851_ RGEPP 856_ PPVRR 861_ PGRTS 866_ DGHCP 871_ LHPPH 876_ ALSNS 881_ SVDLG 886_ SPSLA 891_ SHPRG 896_ LLQNR 901_ GLNND 906_ SPERR 911_ RRPGH 916_ GSLTN 921_ ISRHD 926_ SLKKI 931_ DSPPI 936_ RRSTS 941_ SGQYT 946_ GFNDH 951_ KPLDP 956_ ETIAQ 961_ DIEET 966_ MNTAL 971_ NELRE 976_ LERQS 981_ TAKHA 986_ PDVVL 991_ DTLEQ 996_ VKNSP 1001_ TPATS 1006_ TESLS 1011_ PLHNV 1016_ ALRSS 1021_ EPQIR 1026_ RSTSS 1031_ SSDTM 1036_ STFKP 1041_ MVAPR 1046_ MGVQL 1051_ KPPAL 1056_ RPKPA 1061_ VLPKT 1066_ NPTIG 1071_ PAPPP 1076_QGPTD
1: GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42