E3 ubiquitin-protein ligase RBBP6 (EC 2.3.2.27) (Proliferation potential-related protein) (Protein P2P-R) (RING-type E3 ubiquitin transferase RBBP6) (Retinoblastoma-binding Q protein 1) (RBQ-1) (Retinoblastoma-binding protein 6) (p53-associated cellular protein of testis)
1_MSCVH 6_ YKFSS 11_ KLNYD 16_ TVTFD 21_ GLHIS 26_ LCDLK 31_ KQIMG 36_ REKLK 41_ AADCD 46_ LQITN 51_ AQTKE 56_ EYTDD 61_ NALIP 66_ KNSSV 71_ IVRRI 76_ PIGGV 81_ KSTSK 86_ TYVIS 91_ RTEPA 96_ MATTK 101_ AIDDS 106_ SASIS 111_ LAQLT 116_ KTANL 121_ AEANA 126_ SEEDK 131_ IKAMM 136_ SQSGH 141_ EYDPI 146_ NYMKK 151_ PLGPP 156_ PPSYT 161_ CFRCG 166_ KPGHY 171_ IKNCP 176_ TNGDK 181_ NFESG 186_ PRIKK 191_ STGIP 196_ RSFMM 201_ EVKDP 206_ NMKGA 211_ MLTNT 216_ GKYAI 221_ PTIDA 226_ EAYAI 231_ GKKEK 236_ PPFLP 241_ EEPSS 246_ SSEED 251_ DPIPD 256_ ELLCL 261_ ICKDI 266_ MTDAV 271_ VIPCC 276_ GNSYC 281_ DECIR 286_ TALLE 291_ SDEHT 296_ CPTCH 301_ QNDVS 306_ PDALI 311_ ANKFL 316_ RQAVN 321_ NFKNE 326_ TGYTK 331_ RLRKQ 336_ LPPPP 341_ PPIPP 346_ PRPLI 351_ QRNLQ 356_ PLMRS 361_ PISRQ 366_ QDPLM 371_ IPVTS 376_ SSTHP 381_ APSIS 386_ SLTSN 391_ QSSLA 396_ PPVSG 401_ NPSSA 406_ PAPVP 411_ DITAT 416_ VSISV 421_ HSEKS 426_ DGPFR 431_ DSDNK 436_ ILPAA 441_ ALASE 446_ HSKGT 451_ SSIAI 456_ TALME 461_ EKGYQ 466_ VPVLG 471_ TPSLL 476_ GQSLL 481_ HGQLI 486_ PTTGP 491_ VRINT 496_ ARPGG 501_ GRPGW 506_ EHSNK 511_ LGYLV 516_ SPPQQ 521_ IRRGE 526_ RSCYR 531_ SINRG 536_ RHHSE 541_ RSQRT 546_ QGPSL 551_ PATPV 556_ FVPVP 561_ PPPLY 566_ PPPPH 571_ TLPLP 576_ PGVPP 581_ PQFSP 586_ QFPPG 591_ QPPPA 596_ GYSVP 601_ PPGFP 606_ PAPAN 611_ LSTPW 616_ VSSGV 621_ QTAHS 626_ NTIPT 631_ TQAPP 636_ LSREE 641_ FYREQ 646_ RRLKE 651_ EEKKK 656_ SKLDE 661_ FTNDF 666_ AKELM 671_ EYKKI 676_ QKERR 681_ RSFSR 686_ SKSPY 691_ SGSSY 696_ SRSSY 701_ TYSKS 706_ RSGST 711_ RSRSY 716_ SRSFS 721_ RSHSR 726_ SYSRS 731_ PPYPR 736_ RGRGK 741_ SRNYR 746_ SRSRS 751_ HGYHR 756_ SRSRS 761_ PPYRR 766_ YHSRS 771_ RSPQA 776_ FRGQS 781_ PNKRN 786_ VPQGE 791_ TEREY 796_ FNRYR 801_ EVPPP 806_ YDMKA 811_ YYGRS 816_ VDFRD 821_ PFEKE 826_ RYREW 831_ ERKYR 836_ EWYEK 841_ YYKGY 846_ AAGAQ 851_ PRPSA 856_ NRENF 861_ SPERF 866_ LPLNI 871_ RNSPF 876_ TRGRR 881_ EDYVG 886_ GQSHR 891_ SRNIG 896_ SNYPE 901_ KLSAR 906_ DGHNQ 911_ KDNTK 916_ SKEKE 921_ SENAP 926_ GDGKG 931_ NKHKK 936_ HRKRR 941_ KGEES 946_ EGFLN 951_ PELLE 956_ TSRKS 961_ REPTG 966_ VEENK 971_ TDSLF 976_ VLPSR 981_ DDATP 986_ VRDEP 991_ MDAES 996_ ITFKS 1001_ VSEKD 1006_ KRERD 1011_ KPKAK 1016_ GDKTK 1021_ RKNDG 1026_ SAVSK 1031_ KENIV 1036_ KPAKG 1041_ PQEKV 1046_ DGERE 1051_ RSPRS 1056_ EPPIK 1061_ KAKEE 1066_ TPKTD 1071_ NTKSS 1076_ SSSQK 1081_ DEKIT 1086_ GTPRK 1091_ AHSKS 1096_ AKEHQ 1101_ ETKPV 1106_ KEEKV 1111_ KKDYS 1116_ KDVKS 1121_ EKLTT 1126_ KEEKA 1131_ KKPNE 1136_ KNKPL 1141_ DNKGE 1146_ KRKRK 1151_ TEEKG 1156_ VDKDF 1161_ ESSSM 1166_ KISKL 1171_ EVTEI 1176_ VKPSP 1181_ KRKME 1186_ PDTEK 1191_ MDRTP 1196_ EKDKI 1201_ SLSAP 1206_ AKKIK 1211_ LNRET 1216_ GKKIG 1221_ STENI 1226_ SNTKE 1231_ PSEKL 1236_ ESTSS 1241_ KVKQE 1246_ KVKGK 1251_ VRRKV 1256_ TGTEG 1261_ SSSTL 1266_ VDYTS 1271_ TSSTG 1276_ GSPVR 1281_ KSEEK 1286_ TDTKR 1291_ TVIKT 1296_ MEEYN 1301_ NDNTA 1306_ PAEDV 1311_ IIMIQ 1316_ VPQSK 1321_ WDKDD 1326_ FESEE 1331_ EDVKS 1336_ TQPIS 1341_ SVGKP 1346_ ASVIK 1351_ NVSTK 1356_ PSNIV 1361_ KYPEK 1366_ ESEPS 1371_ EKIQK 1376_ FTKDV 1381_ SHEII 1386_ QHEVK 1391_ SSKNS 1396_ ASSEK 1401_ GKTKD 1406_ RDYSV 1411_ LEKEN 1416_ PEKRK 1421_ NSTQP 1426_ EKESN 1431_ LDRLN 1436_ EQGNF 1441_ KSLSQ 1446_ SSKEA 1451_ RTSDK 1456_ HDSTR 1461_ ASSNK 1466_ DFTPN 1471_ RDKKT 1476_ DYDTR 1481_ EYSSS 1486_ KRRDE 1491_ KNELT 1496_ RRKDS 1501_ PSRNK 1506_ DSASG 1511_ QKNKP 1516_ REERD 1521_ LPKKG 1526_ TGDSK 1531_ KSNSS 1536_ PSRDR 1541_ KPHDH 1546_ KATYD 1551_ TKRPN 1556_ EETKS 1561_ VDKNP 1566_ CKDRE 1571_ KHVLE 1576_ ARNNK 1581_ ESSGN 1586_ KLLYI 1591_ LNPPE 1596_ TQVEK 1601_ EQITG 1606_ QIDKS 1611_ TVKPK 1616_ PQLSH 1621_ SSRLS 1626_ SDLTR 1631_ ETDEA 1636_ AFEPD 1641_ YNESD 1646_ SESNV 1651_ SVKEE 1656_ ESSGN 1661_ ISKDL 1666_ KDKIV 1671_ EKAKE 1676_ SLDTA 1681_ AVVQV 1686_ GISRN 1691_ QSHSS 1696_ PSVSP 1701_ SRSHS 1706_ PSGSQ 1711_ TRSHS 1716_ SSASS 1721_ AESQD 1726_ SKKKK 1731_ KKKEK 1736_ KKHKK 1741_ HKKHK 1746_ KHKKH 1751_ AGTEV 1756_ ELEKS 1761_ QKHKH 1766_ KKKKS 1771_ KKNKD 1776_ KEKEK 1781_ EKDDQ 1786_KVKSV
1: E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359)
2: (Microbial infection) [Isoform 1]: Restricts ebolavirus replication probably by impairing the vp30-NP interaction, and thus viral transcription