N-terminal EF-hand calcium-binding protein 2 (EF-hand calcium-binding protein 2) (Neuronal calcium-binding protein 2) (Synaptotagmin-interacting protein 2) (Stip-2)
1_MCERA 6_ ARLCR 11_ AGAHR 16_ LLREP 21_ PQQGR 26_ ALGGL 31_ LRWVG 36_ ARMGE 41_ PRESL 46_ APAAP 51_ ADPGP 56_ ASPRG 61_ GTAVI 66_ LDIFR 71_ RADKN 76_ DDGKL 81_ SLEEF 86_ QLFFA 91_ DGVLN 96_ EKELE 101_ DLFHT 106_ IDSDN 111_ TNHVD 116_ TKELC 121_ DYFVD 126_ HMGDY 131_ EDVLA 136_ SLETL 141_ NHSVL 146_ KAMGY 151_ TKKVY 156_ EGGSN 161_ VDQFV 166_ TRFLL 171_ KETAN 176_ QIQSL 181_ LSSVE 186_ SAVEA 191_ IEEQT 196_ SQLRQ 201_ NHIKP 206_ SHSAA 211_ QTWCG 216_ SPTPA 221_ SAPNH 226_ KLMAM 231_ EQGKT 236_ LPSAT 241_ EDAKE 246_ EGLEA 251_ QISRL 256_ AELIG 261_ RLESK 266_ ALWFD 271_ LQQRL 276_ SDEDG 281_ TNMHL 286_ QLVRQ 291_ EMAVC 296_ PEQLS 301_ EFLDS 306_ LRQYL 311_ RGTTG 316_ VRNCF 321_ HITAV 326_ RLSDG 331_ FTFVI 336_ YEFWE 341_ TEEAW 346_ KRHLQ 351_ SPLCK 356_ AFRHV 361_ KVDTL 366_ SQPEA 371_ LSRIL 376_ VPAAW 381_CTVGR
1: May act as a signaling scaffold protein that senses intracellular calcium. Can modulate ligand-induced internalization of ADORA2A and coupling efficiency of mGluR5/GRM5; for both receptors may regulate signaling activity such as promoting MAPK1/3 (ERK1/2) activation