E3 ubiquitin-protein ligase SH3RF1 (EC 2.3.2.27) (Plenty of SH3s) (Protein POSH) (RING finger protein 142) (RING-type E3 ubiquitin transferase SH3RF1) (SH3 domain-containing RING finger protein 1) (SH3 multiple domains protein 2)
1_MDESA 6_ LLDLL 11_ ECPVC 16_ LERLD 21_ ASAKV 26_ LPCQH 31_ TFCKR 36_ CLLGI 41_ VGSRN 46_ ELRCP 51_ ECRTL 56_ VGSGV 61_ EELPS 66_ NILLV 71_ RLLDG 76_ IKQRP 81_ WKPGP 86_ GGGSG 91_ TNCTN 96_ ALRSQ 101_ SSTVA 106_ NCSSK 111_ DLQSS 116_ QGGQQ 121_ PRVQS 126_ WSPPV 131_ RGIPQ 136_ LPCAK 141_ ALYNY 146_ EGKEP 151_ GDLKF 156_ SKGDI 161_ IILRR 166_ QVDEN 171_ WYHGE 176_ VNGIH 181_ GFFPT 186_ NFVQI 191_ IKPLP 196_ QPPPQ 201_ CKALY 206_ DFEVK 211_ DKEAD 216_ KDCLP 221_ FAKDD 226_ VLTVI 231_ RRVDE 236_ NWAEG 241_ MLADK 246_ IGIFP 251_ ISYVE 256_ FNSAA 261_ KQLIE 266_ WDKPP 271_ VPGVD 276_ AGECS 281_ SAAAQ 286_ SSTAP 291_ KHSDT 296_ KKNTK 301_ KRHSF 306_ TSLTM 311_ ANKSS 316_ QASQN 321_ RHSME 326_ ISPPV 331_ LISSS 336_ NPTAA 341_ ARISE 346_ LSGLS 351_ CSAPS 356_ QVHIS 361_ TTGLI 366_ VTPPP 371_ SSPVT 376_ TGPSF 381_ TFPSD 386_ VPYQA 391_ ALGTL 396_ NPPLP 401_ PPPLL 406_ AATVL 411_ ASTPP 416_ GATAA 421_ AAAAG 426_ MGPRP 431_ MAGST 436_ DQIAH 441_ LRPQT 446_ RPSVY 451_ VAIYP 456_ YTPRK 461_ EDELE 466_ LRKGE 471_ MFLVF 476_ ERCQD 481_ GWFKG 486_ TSMHT 491_ SKIGV 496_ FPGNY 501_ VAPVT 506_ RAVTN 511_ ASQAK 516_ VPMST 521_ AGQTS 526_ RGVTM 531_ VSPST 536_ AGGPA 541_ QKLQG 546_ NGVAG 551_ SPSVV 556_ PAAVV 561_ SAAHI 566_ QTSPQ 571_ AKVLL 576_ HMTGQ 581_ MTVNQ 586_ ARNAV 591_ RTVAA 596_ HNQER 601_ PTAAV 606_ TPIQV 611_ QNAAG 616_ LSPAS 621_ VGLSH 626_ HSLAS 631_ PQPAP 636_ LMPGS 641_ ATHTA 646_ AISIS 651_ RASAP 656_ LACAA 661_ AAPLT 666_ SPSIT 671_ SASLE 676_ AEPSG 681_ RIVTV 686_ LPGLP 691_ TSPDS 696_ ASSAC 701_ GNSSA 706_ TKPDK 711_ DSKKE 716_ KKGLL 721_ KLLSG 726_ ASTKR 731_ KPRVS 736_ PPASP 741_ TLEVE 746_ LGSAE 751_ LPLQG 756_ AVGPE 761_ LPPGG 766_ GHGRA 771_ GSCPV 776_ DGDGP 781_ VTTAV 786_ AGAAL 791_ AQDAF 796_ HRKAS 801_ SLDSA 806_ VPIAP 811_ PPRQA 816_ CSSLG 821_ PVLNE 826_ SRPVV 831_ CERHR 836_ VVVSY 841_ PPQSE 846_ AELEL 851_ KEGDI 856_ VFVHK 861_ KREDG 866_ WFKGT 871_ LQRNG 876_ KTGLF 881_PGSFV
1: Has E3 ubiquitin-protein ligase activity. In the absence of an external substrate, it can catalyze self-ubiquitination (PubMed:15659549, PubMed:20696164). Stimulates ubiquitination of potassium channel KCNJ1, enhancing it's dynamin-dependent and clathrin-independent endocytosis (PubMed:19710010). Acts as a scaffold protein that coordinates with MAPK8IP1/JIP1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the differentiation of CD4(+) and CD8(+) T-cells and promotes T-helper 1 (Th1) cell differentiation. Regulates the activation of MAPK8/JNK1 and MAPK9/JNK2 in CD4(+) T-cells and the activation of MAPK8/JNK1 in CD8(+) T-cells. Plays a crucial role in the migration of neocortical neurons in the developing brain. Controls proper cortical neuronal migration and the formation of proximal cytoplasmic dilation in the leading process (PCDLP) in migratory neocortical neurons by regulating the proper localization of activated RAC1 and F-actin assembly (By similarity)
2: (Microbial infection) Plays an essential role in the targeting of HIV-1 Gag to the plasma membrane, this function is dependent on it's RING domain, and hence it's E3 ligase activity