FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4)
1_MKGAS 6_ EEKLA 11_ SVSNL 16_ VTVFE 21_ NSRTP 26_ EAAPR 31_ GQRLE 36_ DVHHR 41_ PECRP 46_ PESPG 51_ PREKT 56_ NVGEA 61_ VGSEP 66_ RTVSR 71_ RYLNS 76_ LKNKL 81_ SSEAW 86_ RKSCQ 91_ PVTLS 96_ GSGTQ 101_ EPEKK 106_ IVQEL 111_ LETEQ 116_ AYVAR 121_ LHLLD 126_ QVFFQ 131_ ELLKT 136_ ARSSK 141_ AFPED 146_ VVRVI 151_ FSNIS 156_ SIYQF 161_ HSQFF 166_ LPELQ 171_ RRLDD 176_ WTANP 181_ RIGDV 186_ IQKLA 191_ PFLKM 196_ YSEYV 201_ KNFER 206_ AAELL 211_ ATWTD 216_ KSPLF 221_ QEVLT 226_ RIQSS 231_ EASGS 236_ LTLQH 241_ HMLEP 246_ VQRIP 251_ RYELL 256_ LKEYI 261_ QKLPA 266_ QAPDQ 271_ ADAQK 276_ ALDMI 281_ FSAAQ 286_ HSNAA 291_ ITEME 296_ RLQDL 301_ WEVYQ 306_ RLGLE 311_ DDIVD 316_ PSNTL 321_ LREGP 326_ VLKIS 331_ FRRND 336_ PMERY 341_ LFLFN 346_ NMLLY 351_ CVPRV 356_ IQVGA 361_ QFQVR 366_ TRIDV 371_ AGMKV 376_ RELMD 381_ AEFPH 386_ SFLVS 391_ GKQRT 396_ LELQA 401_ RSQEE 406_ MISWM 411_ QAFQA 416_ AIDQI 421_ EKRNE 426_ TFKAA 431_ AQGPE 436_ GDIQE 441_ QELQS 446_ EELGL 451_ RAPQW 456_ VRDKM 461_ VTMCM 466_ RCQEP 471_ FNALT 476_ RRRHH 481_ CRACG 486_ YVVCA 491_ RCSDY 496_ RAELK 501_ YDDNR 506_ PNRVC 511_ LHCYA 516_ FLTGN 521_ VLPEA 526_ KEDKR 531_ RGILE 536_ KGSSA 541_ TPDQS 546_ LMCSF 551_ LQLIG 556_ DKWGK 561_ SGPRG 566_ WCVIP 571_ RDDPL 576_ VLYVY 581_ AAPQD 586_ MRAHT 591_ SIPLL 596_ GYQVT 601_ VGPQG 606_ DPRVF 611_ QLQQS 616_ GQLYT 621_ FKAET 626_ EELKG 631_ RWVKA 636_ MERAA 641_ SGWSP 646_SWPND
1: Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Activates JNK1 via CDC42 but not RAC1. Binds to phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (By similarity)