E3 ubiquitin-protein ligase E3D (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase E3D) (UbcH10-binding protein with a HECT-like domain) (Ubiquitin-conjugating enzyme E2C-binding protein)
1_MAASA 6_ AETRV 11_ FLEVR 16_ GQLQS 21_ ALLIL 26_ GEPKE 31_ GGMPM 36_ NISIM 41_ PSSLQ 46_ MKTPE 51_ GCTEI 56_ QLPAE 61_ VRLVP 66_ SSCRG 71_ LQFVV 76_ GDGLH 81_ LRLQT 86_ QAKLG 91_ TKLIS 96_ MFNQS 101_ SQTQE 106_ CCTFY 111_ CQSCG 116_ EVIIK 121_ DRKLL 126_ RVLPL 131_ PSENW 136_ GALVG 141_ EWCCH 146_ PDPFA 151_ NKSLH 156_ PQEND 161_ CFIGD 166_ SFFLV 171_ NLRTS 176_ LWQQR 181_ PELSP 186_ VEMCC 191_ VSSDN 196_ HCKLE 201_ PKANT 206_ KVICK 211_ RCKVM 216_ LGETV 221_ SSETT 226_ KFYMT 231_ EIIIQ 236_ SSERS 241_ FPIIP 246_ RSWFV 251_ QSVIA 256_ QCLVQ 261_ LSSAR 266_ STFRF 271_ TIQGQ 276_ DDKVY 281_ ILLWL 286_ LNSDS 291_ LVIES 296_ LRNSK 301_ YIKKF 306_ PLLEN 311_ TFKAD 316_ SSSAW 321_ SAVKV 326_ LYQPC 331_ IKSRN 336_ EKLVS 341_ LWESD 346_ ISVHP 351_ LTLPS 356_ ATCLE 361_ LLLIL 366_ SKSNA 371_ NLPSS 376_ LRRVN 381_SFQVA
1: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome (PubMed:15749827). Independently of its E3 ubiquitin-protein ligase activity, acts as an inhibitor of CPSF3 endonuclease activity by blocking CPSF3 active site (PubMed:39032490)