tRNA-splicing endonuclease subunit Sen54 (SEN54 homolog) (HsSEN54) (tRNA-intron endonuclease Sen54)
1_MEPEP 6_ EPAAV 11_ EVPAG 16_ RVLSA 21_ RELFA 26_ ARSRS 31_ QKLPQ 36_ RSHGP 41_ KDFLP 46_ DGSAA 51_ QAERL 56_ RRCRE 61_ ELWQL 66_ LAEQR 71_ VERLG 76_ SLVAA 81_ EWRPE 86_ EGFVE 91_ LKSPA 96_ GKFWQ 101_ TMGFS 106_ EQGRQ 111_ RLHPE 116_ EALYL 121_ LECGS 126_ IHLFH 131_ QDLPL 136_ SIQEA 141_ YQLLL 146_ TDHTV 151_ TFLQY 156_ QVFSH 161_ LKRLG 166_ YVVRR 171_ FQPSS 176_ VLSPY 181_ ERQLN 186_ LDASV 191_ QHLED 196_ GDGKR 201_ KRSSS 206_ SPRSI 211_ NKKAK 216_ ALDNS 221_ LQPKS 226_ LAASS 231_ PPPCS 236_ QPSQC 241_ PEEKP 246_ QESSP 251_ MKGPG 256_ GPFQL 261_ LGSLG 266_ PSPGP 271_ AREGV 276_ GCSWE 281_ SGRAE 286_ NGVTG 291_ AGKRR 296_ WNFEQ 301_ ISFPN 306_ MASDS 311_ RHTLL 316_ RAPAP 321_ ELLPA 326_ NVAGR 331_ ETDAE 336_ SWCQK 341_ LNQRK 346_ EKLSR 351_ REREH 356_ HAEAA 361_ QFQED 366_ VNADP 371_ EVQRC 376_ SSWRE 381_ YKELL 386_ QRRQV 391_ QRSQR 396_ RAPHL 401_ WGQPV 406_ TPLLS 411_ PGQAS 416_ SPAVV 421_ LQHIS 426_ VLQTT 431_ HLPDG 436_ GARLL 441_ EKSGG 446_ LEIIF 451_ DVYQA 456_ DAVAT 461_ FRKNN 466_ PGKPY 471_ ARMCI 476_ SGFDE 481_ PVPDL 486_ CSLKR 491_ LSYQS 496_ GDVPL 501_ IFALV 506_ DHGDI 511_ SFYSF 516_ RDFTL 521_PQDVG
1: Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events