Notch-regulated ankyrin repeat-containing protein
1_MSQAE 6_ LSTCS 11_ APQTQ 16_ RIFQE 21_ AVRKG 26_ NTQEL 31_ QSLLQ 36_ NMTNC 41_ EFNVN 46_ SFGPE 51_ GQTAL 56_ HQSVI 61_ DGNLE 66_ LVKLL 71_ VKFGA 76_ DIRLA 81_ NRDGW 86_ SALHI 91_ AAFGG 96_ HQDIV 101_ LYLIT 106_KAKYA
1: Downstream effector of Notch signaling. Involved in the regulation of liver cancer cells self-renewal (PubMed:25985737). Involved in angiogenesis acting downstream of Notch at branch points to regulate vascular density. Proposed to integrate endothelial Notch and Wnt signaling to control stalk cell proliferation and to stablilize new endothelial connections during angiogenesis (PubMed:19154719). During somitogenesis involved in maintenance of proper somite segmentation and proper numbers of somites and vertebrae. Required for proper anterior-posterior somite patterning. Proposed to function in a negative feedback loop to destabilize Notch 1 intracellular domain (NICD) and down-regulate the Notch signal, preventing expansion of the Notch signal into the anterior somite domain (By similarity)