Arpin (Arp2/3 inhibition protein)
1_MSRIY 6_ HDGAL 11_ RNKAV 16_ QSVRL 21_ PGAWD 26_ PAAHQ 31_ GGNGV 36_ LLEGE 41_ LIDVS 46_ RHSIL 51_ DTHGR 56_ KERYY 61_ VLYIR 66_ PSHIH 71_ RRKFD 76_ AKGNE 81_ IEPNF 86_ SATRK 91_ VNTGF 96_ LMSSY 101_ KVEAK 106_ GDTDR 111_ LTPEA 116_ LKGLV 121_ NKPEL 126_ LALTE 131_ SLTPD 136_ HTVAF 141_ WMPES 146_ EMEVM 151_ ELELG 156_ AGVRL 161_ KTRGD 166_ GPFLD 171_ SLAKL 176_ EAGTV 181_ TKCNF 186_ TGDGK 191_ TGASW 196_ TDNIM 201_ AQKCS 206_ KGAAA 211_ EIREQ 216_ GDGAE 221_DEEWD
1: Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors. Participates in an incoherent feedforward loop at the lamellipodium tip where it inhibits the ARP2/2 complex in response to Rac signaling and where Rac also stimulates actin polymerization through the WAVE complex. Involved in steering cell migration by controlling its directional persistence