E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1)
1_MKVDR 6_ TKLKK 11_ TPTEA 16_ PADCR 21_ ALIDK 26_ LKVCN 31_ DEQLL 36_ LELQQ 41_ IKTWN 46_ IGKCE 51_ LYHWV 56_ DLLDR 61_ FDGIL 66_ ADAGQ 71_ TVENM 76_ SWMLV 81_ CDRPE 86_ REQLK 91_ MLLLA 96_ VLNFT 101_ ALLIE 106_ YSFSR 111_ HLYSS 116_ IEHLT 121_ TLLAS 126_ SDMQV 131_ VLAVL 136_ NLLYV 141_ FSKRS 146_ NYITR 151_ LGSDK 156_ RTPLL 161_ TRLQH 166_ LAESW 171_ GGKEN 176_ GFGLA 181_ ECCRD 186_ LHMMK 191_ YPPSA 196_ TTLHF 201_ EFYAD 206_ PGAEV 211_ KIEKR 216_ TTSNT 221_ LHYIH 226_ IEQLD 231_ KISES 236_ PSEIM 241_ ESLTK 246_ MYSIP 251_ KDKQM 256_ LLFTH 261_ IRLAH 266_ GFSNH 271_ RKRLQ 276_ AVQAR 281_ LHAIS 286_ ILVYS 291_ NALQE 296_ SANSI 301_ LYNGL 306_ IEELV 311_ DVLQI 316_ TDKQL 321_ MEIKA 326_ ASLRT 331_ LTSIV 336_ HLERT 341_ PKLSS 346_ IIDCT 351_ GTASY 356_ HGFLP 361_ VLVRN 366_ CIQAM 371_ IDPSM 376_ DPYPH 381_ QFATA 386_ LFSFL 391_ YHLAS 396_ YDAGG 401_ EALVS 406_ CGMME 411_ ALLKV 416_ IKFLG 421_ DEQDQ 426_ ITFVT 431_ RAVRV 436_ VDLIT 441_ NLDMA 446_ AFQSH 451_ SGLSI 456_ FIYRL 461_ EHEVD 466_ LCRKE 471_ CPFVI 476_ KPKIQ 481_ RPNTT 486_ QEGEE 491_ METDM 496_ DGVQC 501_ IPQRA 506_ ALLKS 511_ MLNFL 516_ KKAIQ 521_ DPAFS 526_ DGIRH 531_ VMDGS 536_ LPTSL 541_ KHIIS 546_ NAEYY 551_ GPSLF 556_ LLATE 561_ VVTVF 566_ VFQEP 571_ SLLSS 576_ LQDNG 581_ LTDVM 586_ LHALL 591_ IKDVP 596_ ATREV 601_ LGSLP 606_ NVFSA 611_ LCLNA 616_ RGLQS 621_ FVQCQ 626_ PFERL 631_ FKVLL 636_ SPDYL 641_ PAMRR 646_ RRSSD 651_ PLGDT 656_ ASNLG 661_ SAVDE 666_ LMRHQ 671_ PTLKT 676_ DATTA 681_ IIKLL 686_ EEICN 691_ LGRDP 696_ KYICQ 701_ KPSIQ 706_ KADGT 711_ ATAPP 716_ PRSNH 721_ AAEEA 726_ SSEDE 731_ EEEEV 736_ QAMQS 741_ FNSTQ 746_ QNETE 751_ PNQQV 756_ VGTEE 761_ RIPIP 766_ LMDYI 771_ LNVMK 776_ FVESI 781_ LSNNT 786_ TDDHC 791_ QEFVN 796_ QKGLL 801_ PLVTI 806_ LGLPN 811_ LPIDF 816_ PTSAA 821_ CQAVA 826_ GVCKS 831_ ILTLS 836_ HEPKV 841_ LQEGL 846_ LQLDS 851_ ILSSL 856_ EPLHR 861_ PIESP 866_ GGSVL 871_ LRELA 876_ CAGNV 881_ ADATL 886_ SAQAT 891_ PLLHA 896_ LTAAH 901_ AYIMM 906_ FVHTC 911_ RVGQS 916_ EIRSI 921_ SVNQW 926_ GSQLG 931_ LSVLS 936_ KLSQL 941_ YCSLV 946_ WESTV 951_ LLSLC 956_ TPNSL 961_ PSGCE 966_ FGQAD 971_ MQKLV 976_ PKDEK 981_ AGTTQ 986_ GGKRS 991_ DGEQD 996_ GAAGS 1001_ MDAST 1006_ QGLLE 1011_ GIGLD 1016_ GDTLA 1021_ PMETD 1026_ EPTAS 1031_ DSKGK 1036_ SKITP 1041_ AMAAR 1046_ IKQIK 1051_ PLLSA 1056_ SSRLG 1061_ RALAE 1066_ LFGLL 1071_ VKLCV 1076_ GSPVR 1081_ QRRSH 1086_ HAAST 1091_ TTAPT 1096_ PAARS 1101_ TASAL 1106_ TKLLT 1111_ KGLSW 1116_ QPPPY 1121_ TPTPR 1126_ FRLTF 1131_ FICSV 1136_ GFTSP 1141_ MLFDE 1146_ RKYPY 1151_ HLMLQ 1156_ KFLCS 1161_ GGHNA 1166_ LFETF 1171_ NWALS 1176_ MGGKV 1181_ PVSEG 1186_ LEHSD 1191_ LPDGT 1196_ GEFLD 1201_ AWLML 1206_ VEKMV 1211_ NPTTV 1216_ LESPH 1221_ SLPAK 1226_ LPGGV 1231_ QNFPQ 1236_ FSALR 1241_ FLVVT 1246_ QKAAF 1251_ TCIKN 1256_ LWNRK 1261_ PLKVY 1266_ GGRMA 1271_ ESMLA 1276_ ILCHI 1281_ LRGEP 1286_ VIRER 1291_ LSKEK 1296_ EGSRG 1301_ EEDTG 1306_ QEEGG 1311_ SRREP 1316_ QVNQQ 1321_ QLQQL 1326_ MDMGF 1331_ TREHA 1336_ MEALL 1341_ NTSTM 1346_ EQATE 1351_ YLLTH 1356_ PPPIM 1361_ GGVVR 1366_ DLSMS 1371_ EEDQM 1376_ MRAIA 1381_ MSLGQ 1386_ DIPMD 1391_ QRAES 1396_ PEEVA 1401_ CRKEE 1406_ EERKA 1411_ REKQE 1416_ EEEAK 1421_ CLEKF 1426_ QDADP 1431_ LEQDE 1436_ LHTFT 1441_ DTMLP 1446_ GCFHL 1451_ LDELP 1456_ DTVYR 1461_ VCDLI 1466_ MTAIK 1471_ RNGAD 1476_ YRDMI 1481_ LKQVV 1486_ NQVWE 1491_ AADVL 1496_ IKAAL 1501_ PLTTS 1506_ DTKTV 1511_ SEWIS 1516_ QMATL 1521_ PQASN 1526_ LATRI 1531_ LLLTL 1536_ LFEEL 1541_ KLPCA 1546_ WVVES 1551_ SGILN 1556_ VLIKL 1561_ LEVVQ 1566_ PCLQA 1571_ AKEQK 1576_ EVQTP 1581_ KWITP 1586_ VLLLI 1591_ DFYEK 1596_ TAISS 1601_ KRRAQ 1606_ MTKYL 1611_ QSNSN 1616_ NWRWF 1621_ DDRSG 1626_ RWCSY 1631_ SASNN 1636_ STIDS 1641_ AWKSG 1646_ ETSVR 1651_ FTAGR 1656_ RRYTV 1661_ QFTTM 1666_ VQVNE 1671_ ETGNR 1676_ RPVML 1681_ TLLRV 1686_ PRLNK 1691_ NSKNS 1696_ NGQEL 1701_ EKTLE 1706_ ESKEM 1711_ DIKRK 1716_ ENKGN 1721_ DTPLA 1726_ LESTN 1731_ TEKET 1736_ SLEET 1741_ KIGEI 1746_ LIQGL 1751_ TEDMV 1756_ TVLIR 1761_ ACVSM 1766_ LGVPV 1771_ DPDTL 1776_ HATLR 1781_ LCLRL 1786_ TRDHK 1791_ YAMMF 1796_ AELKS 1801_ TRMIL 1806_ NLTQS 1811_ SGFNG 1816_ FTPLV 1821_ TLLLR 1826_ HIIED 1831_ PCTLR 1836_ HTMEK 1841_ VVRSA 1846_ ATSGA 1851_ GSTTS 1856_ GVVSG 1861_ SLGSR 1866_ EINYI 1871_ LRVLG 1876_ PAACR 1881_ NPDIF 1886_ TEVAN 1891_ CCIRI 1896_ ALPAP 1901_ RGSGT 1906_ ASDDE 1911_ FENLR 1916_ IKGPN 1921_ AVQLV 1926_ KTTPL 1931_ KPSPL 1936_ PVIPD 1941_ TIKEV 1946_ IYDML 1951_ NALAA 1956_ YHAPE 1961_ EADKS 1966_ DPKPG 1971_ VMTQE 1976_ VGQLL 1981_ QDMGD 1986_ DVYQQ 1991_ YRSLT 1996_ RQSSD 2001_ FDTQS 2006_ GFSIN 2011_ SQVFA 2016_ ADGAS 2021_ TETSA 2026_ SGTSQ 2031_ GEAST 2036_ PEESR 2041_ DGKKD 2046_ KEGDR 2051_ ASEEG 2056_ KQKGK 2061_ GSKPL 2066_ MPTST 2071_ ILRLL 2076_ AELVR 2081_ SYVGI 2086_ ATLIA 2091_ NYSYT 2096_ VGQSE 2101_ LIKED 2106_ CSVLA 2111_ FVLDH 2116_ LLPHT 2121_ QNAED 2126_ KDTPA 2131_ LARLF 2136_ LASLA 2141_ AAGSG 2146_ TDAQV 2151_ ALVNE 2156_ VKAAL 2161_ GRALA 2166_ MAEST 2171_ EKHAR 2176_ LQAVM 2181_ CIIST 2186_ IMESC 2191_ PSTSS 2196_ FYSSA 2201_ TAKTQ 2206_ HNGMN 2211_ NIIRL 2216_ FLKKG 2221_ LVNDL 2226_ ARVPH 2231_ SLDLS 2236_ SPNMA 2241_ NTVNA 2246_ ALKPL 2251_ ETLSR 2256_ IVNQP 2261_ SSLFG 2266_ SKSAS 2271_ SKNKS 2276_ EQDAQ 2281_ GASQD 2286_ SSSNQ 2291_ QDPGE 2296_ PGEAE 2301_ VQEED 2306_ HDVTQ 2311_ TEVAD 2316_ GDIMD 2321_ GEAET 2326_ DSVVI 2331_ AGQPE 2336_ VLSSQ 2341_ EMQVE 2346_ NELED 2351_ LIDEL 2356_ LERDG 2361_ GSGNS 2366_ TIIVS 2371_ RSGED 2376_ ESQED 2381_ VLMDE 2386_ APSNL 2391_ SQAST 2396_ LQANR 2401_ EDSMN 2406_ ILDPE 2411_ DEEEH 2416_ TQEED 2421_ SSGSN 2426_ EDEDD 2431_ SQDEE 2436_ EEEEE 2441_ DEEDD 2446_ QEDDE 2451_ GEEGD 2456_ EDDDD 2461_ DGSEM 2466_ ELDED 2471_ YPDMN 2476_ ASPLV 2481_ RFERF 2486_ DREDD 2491_ LIIEF 2496_ DNMFS 2501_ SATDI 2506_ PPSPG 2511_ NIPTT 2516_ HPLMV 2521_ RHADH 2526_ SSLTL 2531_ GSGSS 2536_ TTRLT 2541_ QGIGR 2546_ SQRTL 2551_ RQLTA 2556_ NTGHT 2561_ IHVHY 2566_ PGNRQ 2571_ PNPPL 2576_ ILQRL 2581_ LGPSA 2586_ AADIL 2591_ QLSSS 2596_ LPLQS 2601_ RGRAR 2606_ LLVGN 2611_ DDVHI 2616_ IARSD 2621_ DELLD 2626_ DFFHD 2631_ QSTAT 2636_ SQAGT 2641_ LSSIP 2646_ TALTR 2651_ WTEEC 2656_ KVLDA 2661_ ESMHD 2666_ CVSVV 2671_ KVSIV 2676_ NHLEF 2681_ LRDEE 2686_ LEERR 2691_ EKRRK 2696_ QLAEE 2701_ ETKIT 2706_ DKGKE 2711_ DKENR 2716_ DQSAQ 2721_ CTASK 2726_ SNDST 2731_ EQNLS 2736_ DGTPM 2741_ PDSYP 2746_ TTPSS 2751_ TDAAT 2756_ SESKE 2761_ TLGTL 2766_ QSSQQ 2771_ QPTLP 2776_ TPPAL 2781_ GEVPQ 2786_ ELQSP 2791_ AGEGG 2796_ SSTQL 2801_ LMPVE 2806_ PEELG 2811_ PTRPS 2816_ GEAET 2821_ TQMEL 2826_ SPAPT 2831_ ITSLS 2836_ PERAE 2841_ DSDAL 2846_ TAVSS 2851_ QLEGS 2856_ PMDTS 2861_ SLASC 2866_ TLEEA 2871_ VGDTS 2876_ AAGSS 2881_ EQPRA 2886_ GSSTP 2891_ GDAPP 2896_ AVAEV 2901_ QGRSD 2906_ GSGES 2911_ AQPPE 2916_ DSSPP 2921_ ASSES 2926_ SSTRD 2931_ SAVAI 2936_ SGADS 2941_ RGILE 2946_ EPLPS 2951_ TSSEE 2956_ EDPLA 2961_ GISLP 2966_ EGVDP 2971_ SFLAA 2976_ LPDDI 2981_ RREVL 2986_ QNQLG 2991_ IRPPT 2996_ RTAPS 3001_ TNSSA 3006_ PAVVG 3011_ NPGVT 3016_ EVSPE 3021_ FLAAL 3026_ PPAIQ 3031_ EEVLA 3036_ QQRAE 3041_ QQRRE 3046_ LAQNA 3051_ SSDTP 3056_ MDPVT 3061_ FIQTL 3066_ PSDLR 3071_ RSVLE 3076_ DMEDS 3081_ VLAVM 3086_ PPDIA 3091_ AEAQA 3096_ LRREQ 3101_ EARQR 3106_ QLMHE 3111_ RLFGH 3116_ SSTSA 3121_ LSAIL 3126_ RSPAF 3131_ TSRLS 3136_ GNRGV 3141_ QYTRL 3146_ AVQRG 3151_ GTFQM 3156_ GGSSS 3161_ HNRPS 3166_ GSNVD 3171_ TLLRL 3176_ RGRLL 3181_ LDHEA 3186_ LSCLL 3191_ VLLFV 3196_ DEPKL 3201_ NTSRL 3206_ HRVLR 3211_ NLCYH 3216_ AQTRH 3221_ WVIRS 3226_ LLSIL 3231_ QRSSE 3236_ SELCI 3241_ ETPKL 3246_ TTSEE 3251_ KGKKS 3256_ SKSCG 3261_ SSSHE 3266_ NRPLD 3271_ LLHKM 3276_ ESKSS 3281_ NQLSW 3286_ LSVSM 3291_ DAALG 3296_ CRTNI 3301_ FQIQR 3306_ SGGRK 3311_ HTEKH 3316_ ASGGS 3321_ TVHIH 3326_ PQAAP 3331_ VVCRH 3336_ VLDTL 3341_ IQLAK 3346_ VFPSH 3351_ FTQQR 3356_ TKETN 3361_ CESDR 3366_ ERGNK 3371_ ACSPC 3376_ SSQSS 3381_ SSGIC 3386_ TDFWD 3391_ LLVKL 3396_ DNMNV 3401_ SRKGK 3406_ NSVKS 3411_ VPVSA 3416_ GGEGE 3421_ TSPYS 3426_ LEASP 3431_ LGQLM 3436_ NMLSH 3441_ PVIRR 3446_ SSLLT 3451_ EKLLR 3456_ LLSLI 3461_ SIALP 3466_ ENKVS 3471_ EAQAN 3476_ SGSGA 3481_ SSTTT 3486_ ATSTT 3491_ STTTT 3496_ TAAST 3501_ TPTPP 3506_ TAPTP 3511_ VTSAP 3516_ ALVAA 3521_ TAIST 3526_ IVVAA 3531_ STTVT 3536_ TPTTA 3541_ TTTVS 3546_ ISPTT 3551_ KGSKS 3556_ PAKVS 3561_ DGGSS 3566_ STDFK 3571_ MVSSG 3576_ LTENQ 3581_ LQLSV 3586_ EVLTS 3591_ HSCSE 3596_ EGLED 3601_ AANVL 3606_ LQLSR 3611_ GDSGT 3616_ RDTVL 3621_ KLLLN 3626_ GARHL 3631_ GYTLC 3636_ KQIGT 3641_ LLAEL 3646_ REYNL 3651_ EQQRR 3656_ AQCET 3661_ LSPDG 3666_ LPEEQ 3671_ PQTTK 3676_ LKGKM 3681_ QSRFD 3686_ MAENV 3691_ VIVAS 3696_ QKRPL 3701_ GGREL 3706_ QLPSM 3711_ SMLTS 3716_ KTSTQ 3721_ KFFLR 3726_ VLQVI 3731_ IQLRD 3736_ DTRRA 3741_ NKKAK 3746_ QTGRL 3751_ GSSGL 3756_ GSASS 3761_ IQAAV 3766_ RQLEA 3771_ EADAI 3776_ IQMVR 3781_ EGQRA 3786_ RRQQQ 3791_ AATSE 3796_ SSQSE 3801_ ASVRR 3806_ EESPM 3811_ DVDQP 3816_ SPSAQ 3821_ DTQSI 3826_ ASDGT 3831_ PQGEK 3836_ EKEER 3841_ PPELP 3846_ LLSEQ 3851_ LSLDE 3856_ LWDML 3861_ GECLK 3866_ ELEES 3871_ HDQHA 3876_ VLVLQ 3881_ PAVEA 3886_ FFLVH 3891_ ATERE 3896_ SKPPV 3901_ RDTRE 3906_ SQLAH 3911_ IKDEP 3916_ PPLSP 3921_ APLTP 3926_ ATPSS 3931_ LDPFF 3936_ SREPS 3941_ SMHIS 3946_ SSLPP 3951_ DTQKF 3956_ LRFAE 3961_ THRTV 3966_ LNQIL 3971_ RQSTT 3976_ HLADG 3981_ PFAVL 3986_ VDYIR 3991_ VLDFD 3996_ VKRKY 4001_ FRQEL 4006_ ERLDE 4011_ GLRKE 4016_ DMAVH 4021_ VRRDH 4026_ VFEDS 4031_ YRELH 4036_ RKSPE 4041_ EMKNR 4046_ LYIVF 4051_ EGEEG 4056_ QDAGG 4061_ LLREW 4066_ YMIIS 4071_ REMFN 4076_ PMYAL 4081_ FRTSP 4086_ GDRVT 4091_ YTINP 4096_ SSHCN 4101_ PNHLS 4106_ YFKFV 4111_ GRIVA 4116_ KAVYD 4121_ NRLLE 4126_ CYFTR 4131_ SFYKH 4136_ ILGKS 4141_ VRYTD 4146_ MESED 4151_ YHFYQ 4156_ GLVYL 4161_ LENDV 4166_ STLGY 4171_ DLTFS 4176_ TEVQE 4181_ FGVCE 4186_ VRDLK 4191_ PNGAN 4196_ ILVTE 4201_ ENKKE 4206_ YVHLV 4211_ CQMRM 4216_ TGAIR 4221_ KQLAA 4226_ FLEGF 4231_ YEIIP 4236_ KRLIS 4241_ IFTEQ 4246_ ELELL 4251_ ISGLP 4256_ TIDID 4261_ DLKSN 4266_ TEYHK 4271_ YQSNS 4276_ IQIQW 4281_ FWRAL 4286_ RSFDQ 4291_ ADRAK 4296_ FLQFV 4301_ TGTSK 4306_ VPLQG 4311_ FAALE 4316_ GMNGI 4321_ QKFQI 4326_ HRDDR 4331_ STDRL 4336_ PSAHT 4341_ CFNQL 4346_ DLPAY 4351_ ESFEK 4356_ LRHML 4361_ LLAIQ 4366_ECSEG
1: E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity)