Transcription initiation factor TFIID subunit 8 (Protein taube nuss) (TBP-associated factor 43 kDa) (TBP-associated factor 8) (Transcription initiation factor TFIID 43 kDa subunit) (TAFII-43) (TAFII43) (hTAFII43)
1_MADAA 6_ ATAGA 11_ GGSGT 16_ RSGSK 21_ QSTNP 26_ ADNYH 31_ LARRR 36_ TLQVV 41_ VSSLL 46_ TEAGF 51_ ESAEK 56_ ASVET 61_ LTEML 66_ QSYIS 71_ EIGRS 76_ AKSYC 81_ EHTAR 86_ TQPTL 91_ SDIVV 96_ TLVEM 101_ GFNVD 106_ TLPAY 111_ AKRSQ 116_ RMVIT 121_ APPVT 126_ NQPVT 131_ PKALT 136_ AGQNR 141_ PHPPH 146_ IPSHF 151_ PEFPD 156_ PHTYI 161_ KTPTY 166_ REPVS 171_ DYQVL 176_ REKAA 181_ SQRRD 186_ VERAL 191_ TRFMA 196_ KTGET 201_ QSLFK 206_ DDVST 211_ FPLIA 216_ ARPFT 221_ IPYLT 226_ ALLPS 231_ ELEMQ 236_ QMEET 241_ DSSEQ 246_ DEQTD 251_ TENLA 256_ LHISM 261_ EDSGA 266_ EKENT 271_ SVLQQ 276_ NPSLS 281_ GSRNG 286_ EENII 291_ DNPYL 296_ RPVKK 301_PKIRR
1: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C (PubMed:33795473). TAF8 is involved in forming the TFIID-B module, together with TAF5 (PubMed:33795473). Mediates both basal and activator-dependent transcription (PubMed:14580349). Plays a role in the differentiation of preadipocyte fibroblasts to adipocytes, however, does not seem to play a role in differentiation of myoblasts (PubMed:14580349). Required for the integration of TAF10 in the TAF complex (PubMed:14580349). May be important for survival of cells of the inner cell mass which constitute the pluripotent cell population of the early embryo (By similarity)