V-set domain-containing T-cell activation inhibitor 1 (B7 homolog 4) (B7-H4) (B7h.5) (Immune costimulatory protein B7-H4) (Protein B7S1) (T-cell costimulatory molecule B7x)
1_MASLG 6_ QILFW 11_ SIISI 16_ IIILA 21_ GAIAL 26_ IIGFG 31_ ISGRH 36_ SITVT 41_ TVASA 46_ GNIGE 51_ DGILS 56_ CTFEP 61_ DIKLS 66_ DIVIQ 71_ WLKEG 76_ VLGLV 81_ HEFKE 86_ GKDEL 91_ SEQDE 96_ MFRGR 101_ TAVFA 106_ DQVIV 111_ GNASL 116_ RLKNV 121_ QLTDA 126_ GTYKC 131_ YIITS 136_ KGKGN 141_ ANLEY 146_ KTGAF 151_ SMPEV 156_ NVDYN 161_ ASSET 166_ LRCEA 171_ PRWFP 176_ QPTVV 181_ WASQV 186_ DQGAN 191_ FSEVS 196_ NTSFE 201_ LNSEN 206_ VTMKV 211_ VSVLY 216_ NVTIN 221_ NTYSC 226_ MIEND 231_ IAKAT 236_ GDIKV 241_ TESEI 246_ KRRSH 251_ LQLLN 256_ SKASL 261_ CVSSF 266_ FAISW 271_ ALLPL 276_SPYLM
1: Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation