Cytokine-dependent hematopoietic cell linker (Mast cell immunoreceptor signal transducer)
1_MNRQG 6_ NRKTT 11_ KEGSN 16_ DLKFQ 21_ NFSLP 26_ KNRSW 31_ PRINS 36_ ATGQY 41_ QRMNK 46_ PLLDW 51_ ERNFA 56_ AVLDG 61_ AKGHS 66_ DDDYD 71_ DPELR 76_ MEETW 81_ QSIKI 86_ LPARP 91_ IKESE 96_ YADTH 101_ YFKVA 106_ MDTPL 111_ PLDTR 116_ TSISI 121_ GQPTW 126_ NTQTR 131_ LERVD 136_ KPISK 141_ DVRSQ 146_ NIKGD 151_ ASVRK 156_ NKIPL 161_ PPPRP 166_ LITLP 171_ KKYQP 176_ LPPEP 181_ ESSRP 186_ PLSQR 191_ HTFPE 196_ VQRMP 201_ SQISL 206_ RDLSE 211_ VLEAE 216_ KVPHN 221_ QRKPE 226_ STHLL 231_ ENQNT 236_ QEIPL 241_ AISSS 246_ SFTTS 251_ NHSVQ 256_ NRDHR 261_ GGMQP 266_ CSPQR 271_ CQPPA 276_ SCSPH 281_ ENILP 286_ YKYTS 291_ WRPPF 296_ PKRSD 301_ RKDVQ 306_ HNEWY 311_ IGEYS 316_ RQAVE 321_ EAFMK 326_ ENKDG 331_ SFLVR 336_ DCSTK 341_ SKEEP 346_ YVLAV 351_ FYENK 356_ VYNVK 361_ IRFLE 366_ RNQQF 371_ ALGTG 376_ LRGDE 381_ KFDSV 386_ EDIIE 391_ HYKNF 396_ PIILI 401_ DGKDK 406_ TGVHR 411_ KQCHL 416_ TQPLP 421_LTRHL
1: An adapter protein which plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation (By similarity). Together with FGR, it acts as a negative regulator of natural killer cell-activating receptors and inhibits interferon-gamma production (By similarity). Acts as a positive regulator of both T-cell receptor and natural killer T (NKT) cell receptor signaling in CD4-positive NKT cells (By similarity). Together with MAP4K1, it enhances CD3-triggered activation of T-cells and subsequent IL2 production (By similarity). May be involved in tumor necrosis factor induced cell death by promoting reactive oxidative species generation, and MLKL oligomerization, ultimately leading to necrosis (By similarity). Involved in phosphorylation of LAT (By similarity). May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells (By similarity)