Schlafen family member 11 (EC 3.6.-.-)
1_MEANQ 6_ CPLVV 11_ EPSYP 16_ DLVIN 21_ VGEVT 26_ LGEEN 31_ RKKLQ 36_ KIQRD 41_ QEKER 46_ VMRAA 51_ CALLN 56_ SGGGV 61_ IRMAK 66_ KVEHP 71_ VEMGL 76_ DLEQS 81_ LRELI 86_ QSSDL 91_ QAFFE 96_ TKQQG 101_ RCFYI 106_ FVKSW 111_ SSGPF 116_ PEDRS 121_ VKPRL 126_ CSLSS 131_ SLYRR 136_ SETSV 141_ RSMDS 146_ REAFC 151_ FLKTK 156_ RKPKI 161_ LEEGP 166_ FHKIH 171_ KGVYQ 176_ ELPNS 181_ DPADP 186_ NSDPA 191_ DLIFQ 196_ KDYLE 201_ YGEIL 206_ PFPES 211_ QLVEF 216_ KQFST 221_ KHFQE 226_ YVKRT 231_ IPEYV 236_ PAFAN 241_ TGGGY 246_ LFIGV 251_ DDKSR 256_ EVLGC 261_ AKENV 266_ DPDSL 271_ RRKIE 276_ QAIYK 281_ LPCVH 286_ FCQPQ 291_ RPITF 296_ TLKIV 301_ NVLKR 306_ GELYG 311_ YACMI 316_ RVNPF 321_ CCAVF 326_ SEAPN 331_ SWIVE 336_ DKYVC 341_ SLTTE 346_ KWVGM 351_ MTDTD 356_ PDLLQ 361_ LSEDF 366_ ECQLS 371_ LSSGP 376_ PLSRP 381_ VYSKK 386_ GLEHK 391_ KELQQ 396_ LLFSV 401_ PPGYL 406_ RYTPE 411_ SLWRD 416_ LISEH 421_ RGLEE 426_ LINKQ 431_ MQPFF 436_ RGILI 441_ FSRSW 446_ AVDLN 451_ LQEKP 456_ GVICD 461_ ALLIA 466_ QNSTP 471_ ILYTI 476_ LREQD 481_ AEGQD 486_ YCTRT 491_ AFTLK 496_ QKLVN 501_ MGGYT 506_ GKVCV 511_ RAKVL 516_ CLSPE 521_ SSAEA 526_ LEAAV 531_ SPMDY 536_ PASYS 541_ LAGTQ 546_ HMEAL 551_ LQSLV 556_ IVLLG 561_ FRSLL 566_ SDQLG 571_ CEVLN 576_ LLTAQ 581_ QYEIF 586_ SRSLR 591_ KNREL 596_ FVHGL 601_ PGSGK 606_ TIMAM 611_ KIMEK 616_ IRNVF 621_ HCEAH 626_ RILYV 631_ CENQP 636_ LRNFI 641_ SDRNI 646_ CRAET 651_ RKTFL 656_ RENFE 661_ HIQHI 666_ VIDEA 671_ QNFRT 676_ EDGDW 681_ YGKAK 686_ SITRR 691_ AKGGP 696_ GILWI 701_ FLDYF 706_ QTSHL 711_ DCSGL 716_ PPLSD 721_ QYPRE 726_ ELTRI 731_ VRNAD 736_ PIAKY 741_ LQKEM 746_ QVIRS 751_ NPSFN 756_ IPTGC 761_ LEVFP 766_ EAEWS 771_ QGVQG 776_ TLRIK 781_ KYLTV 786_ EQIMT 791_ CVADT 796_ CRRFF 801_ DRGYS 806_ PKDVA 811_ VLVST 816_ AKEVE 821_ HYKYE 826_ LLKAM 831_ RKKRV 836_ VQLSD 841_ ACDML 846_ GDHIV 851_ LDSVR 856_ RFSGL 861_ ERSIV 866_ FGIHP 871_ RTADP 876_ AILPN 881_ VLICL 886_ ASRAK 891_ QHLYI 896_FPWGG
1: Inhibitor of DNA replication that promotes cell death in response to DNA damage (PubMed:22927417, PubMed:26658330, PubMed:29395061). Acts as a guardian of the genome by killing cells with defective replication (PubMed:29395061). Persistently blocks stressed replication forks by opening chromatin across replication initiation sites at stressed replication forks, possibly leading to unwind DNA ahead of the MCM helicase and block fork progression, ultimately leading to cell death (PubMed:29395061). Upon DNA damage, inhibits translation of ATR or ATM based on distinct codon usage without disrupting early DNA damage response signaling (PubMed:30374083). Antiviral restriction factor with manganese-dependent type II tRNA endoribonuclease (PubMed:36115853). A single tRNA molecule is bound and cleaved by the SLFN11 dimer (PubMed:36115853). Specifically abrogates the production of retroviruses such as human immunodeficiency virus 1 (HIV-1) by acting as a specific inhibitor of the synthesis of retroviruses encoded proteins in a codon-usage-dependent manner (PubMed:23000900). Impairs the replication of human cytomegalovirus (HCMV) and some Flaviviruses (PubMed:35105802, PubMed:36115853). Exploits the unique viral codon bias towards A/T nucleotides (PubMed:23000900). Also acts as an interferon (IFN)-induced antiviral protein which acts as an inhibitor of retrovirus protein synthesis (PubMed:23000900)