Polycomb group RING finger protein 5 (RING finger protein 159)
1_MATQR 6_ KHLVK 11_ DFNPY 16_ ITCYI 21_ CKGYL 26_ IKPTT 31_ VTECL 36_ HTFCK 41_ TCIVQ 46_ HFEDS 51_ NDCPR 56_ CGNQV 61_ HETNP 66_ LEMLR 71_ LDNTL 76_ EEIIF 81_ KLVPG 86_ LREQE 91_ LERES 96_ EFWKK 101_ NKPQE 106_ NGQDD 111_ TSKAD 116_ KPKVD 121_ EEGDE 126_ NEDDK 131_ DYHRS 136_ DPQIA 141_ ICLDC 146_ LRNNG 151_ QSGDN 156_ VVKGL 161_ MKKFI 166_ RCSTR 171_ VTVGT 176_ IKKFL 181_ SLKLK 186_ LPSSY 191_ ELDVL 196_ CNGEI 201_ MGKDH 206_ TMEFI 211_ YMTRW 216_ RLRGE 221_ NFRCL 226_ NCSAS 231_ QVCSQ 236_ DGPLY 241_ QSYPM 246_ VLQYR 251_PRIDF
1: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:26151332). Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332). Plays a redundant role with PCGF3 as part of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females (By similarity)