Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8) (Nima-related protein kinase 12a)
1_MEKYE 6_ RIRVV 11_ GRGAF 16_ GIVHL 21_ CLRKA 26_ DQKLV 31_ IIKQI 36_ PVEQM 41_ TKEER 46_ QAAQN 51_ ECQVL 56_ KLLNH 61_ PNVIE 66_ YYENF 71_ LEDKA 76_ LMIAM 81_ EYAPG 86_ GTLAE 91_ FIQKR 96_ CNSLL 101_ EEETI 106_ LHFFV 111_ QILLA 116_ LHHVH 121_ THLIL 126_ HRDLK 131_ TQNIL 136_ LDKHR 141_ MVVKI 146_ GDFGI 151_ SKILS 156_ SKSKA 161_ YTVVG 166_ TPCYI 171_ SPELC 176_ EGKPY 181_ NQKSD 186_ IWALG 191_ CVLYE 196_ LASLK 201_ RAFEA 206_ ANLPA 211_ LVLKI 216_ MSGTF 221_ APISD 226_ RYSPE 231_ LRQLV 236_ LSLLS 241_ LEPAQ 246_ RPPLS 251_ HIMAQ 256_ PLCIR 261_ ALLNL 266_ HTDVG 271_ SVRMR 276_ RAEKS 281_ VAPSN 286_ TGSRT 291_ TSVRC 296_ RGIPR 301_ GPVRP 306_ AIPPP 311_ LSSVY 316_ AWGGG 321_ LGTPL 326_ RLPML 331_ NTEVV 336_ QVAAG 341_ RTQKA 346_ GVTRS 351_ GRLIL 356_ WEAPP 361_ LGAGG 366_ GSLLP 371_ GAVEQ 376_ PQPQF 381_ ISRFL 386_ EGQSG 391_ VTIKH 396_ VACGD 401_ FFTAC 406_ LTDRG 411_ IIMTF 416_ GSGSN 421_ GCLGH 426_ GSLTD 431_ ISQPT 436_ IVEAL 441_ LGYEM 446_ VQVAC 451_ GASHV 456_ LALST 461_ ERELF 466_ AWGRG 471_ DSGRL 476_ GLGTR 481_ ESHSC 486_ PQQVP 491_ MPPGQ 496_ EAQRV 501_ VCGID 506_ SSMIL 511_ TVPGQ 516_ ALACG 521_ SNRFN 526_ KLGLD 531_ HLSLG 536_ EEPVP 541_ HQQVE 546_ EALSF 551_ TLLGS 556_ APLDQ 561_ EPLLS 566_ IDLGT 571_ AHSAA 576_ VTASG 581_ DCYTF 586_ GSNQH 591_ GQLGT 596_ NTRRG 601_ SRAPC 606_ KVQGL 611_ EGIKM 616_ AMVAC 621_ GDAFT 626_ VAIGA 631_ ESEVY 636_ SWGKG 641_ ARGRL 646_ GRRDE 651_ DAGLP 656_ RPVQL 661_ DETHP 666_ YTVTS 671_ VSCCH 676_ GNTLL 681_ AVRSV 686_TDEPV
1: Required for renal tubular integrity. May regulate local cytoskeletal structure in kidney tubule epithelial cells. May regulate ciliary biogenesis through targeting of proteins to the cilia (PubMed:37598857). Plays a role in organogenesis, and is involved in the regulation of the Hippo signaling pathway (PubMed:26967905)