Zygote arrest protein 1 (Oocyte-specific maternal effect factor)
1_MAALG 6_ DEVLD 11_ GYVFP 16_ ACPPC 21_ SYRYP 26_ YPAAT 31_ KGKGA 36_ AGGSW 41_ QQRGR 46_ GCLPA 51_ SSPCS 56_ AGAAS 61_ LSFPG 66_ CGRLT 71_ AAEYF 76_ DSYQR 81_ ERLMA 86_ LLAQV 91_ GPGLG 96_ PRARR 101_ AGSCD 106_ VAVQV 111_ SPRID 116_ AAVQC 121_ SLGRR 126_ TLQRR 131_ ARDPE 136_ SPAGP 141_ GAEGT 146_ TGGGS 151_ FSQQP 156_ SRRGL 161_ EQGSP 166_ QNGAP 171_ RPMRF 176_ PRTVA 181_ VYSPL 186_ ALRRL 191_ TAFLE 196_ GPGPA 201_ AGEQR 206_ SGASD 211_ GERGP 216_ PPARL 221_ QGPEE 226_ GEVWT 231_ KKAPR 236_ RPQSD 241_ DDGEA 246_ QAAVR 251_ ASWEQ 256_ PADGP 261_ ELPPR 266_ EAQEG 271_ EAAPR 276_ SALRS 281_ PGQPP 286_ SAGRA 291_ RDGGD 296_ GREAA 301_ VAGEG 306_ PSPRS 311_ PELGK 316_ ERLRF 321_ QFLEQ 326_ KYGYY 331_ HCKDC 336_ NIRWE 341_ SAYVW 346_ CVQGT 351_ NKVYF 356_ KQFCR 361_ TCQKS 366_ YNPYR 371_ VEDIT 376_ CQSCK 381_ QTRCS 386_ CPVKL 391_ RHVDP 396_ KRPHR 401_ QDLCG 406_ RCKGK 411_ RLSCD 416_STFSF
1: mRNA-binding protein that mediates formation of MARDO (mitochondria-associated ribonucleoprotein domain), a membraneless compartment that stores maternal mRNAs in oocytes. MARDO assembly around mitochondria is directed by an increase in mitochondrial membrane potential during oocyte growth. Promotes formation of MARDO phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to maternal mRNAs. Binds to the 3'-UTR of maternal mRNAs. Maternal mRNAs stored in the MARDO are translationally repressed. Essential for female fertility and oocyte-to-embryo transition by coordinating maternal mRNA storage, translation and degradation