Stearoyl-CoA desaturase 5 (EC 1.14.19.1) (Acyl-CoA-desaturase 4) (HSCD5) (Stearoyl-CoA 9-desaturase) (Stearoyl-CoA desaturase 2)
1_MPGPA 6_ TDAGK 11_ IPFCD 16_ AKEEI 21_ RAGLE 26_ SSEGG 31_ GGPER 36_ PGARG 41_ QRQNI 46_ VWRNV 51_ VLMSL 56_ LHLGA 61_ VYSLV 66_ LIPKA 71_ KPLTL 76_ LWAYF 81_ CFLLA 86_ ALGVT 91_ AGAHR 96_ LWSHR 101_ SYRAK 106_ LPLRI 111_ FLAVA 116_ NSMAF 121_ QNDIF 126_ EWSRD 131_ HRAHH 136_ KYSET 141_ DADPH 146_ NARRG 151_ FFFSH 156_ IGWLF 161_ VRKHR 166_ DVIEK 171_ GRKLD 176_ VTDLL 181_ ADPVV 186_ RIQRK 191_ YYKIS 196_ VVLMC 201_ FVVPT 206_ LVPWY 211_ IWGES 216_ LWNSY 221_ FLASI 226_ LRYTI 231_ SLNIS 236_ WLVNS 241_ AAHMY 246_ GNRPY 251_ DKHIS 256_ PRQNP 261_ LVALG 266_ AIGEG 271_ FHNYH 276_ HTFPF 281_ DYSAS 286_ EFGLN 291_ FNPTT 296_ WFIDF 301_ MCWLG 306_ LATDR 311_ KRATK 316_ PMIEA 321_RKART
1: Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:15610069, PubMed:15907797, PubMed:22745828). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids (PubMed:15610069, PubMed:15907797). Involved in neuronal cell proliferation and differentiation through down-regulation of EGFR/AKT/MAPK and Wnt signaling pathways (PubMed:22745828)