Adhesion G-protein coupled receptor G6 (Developmentally regulated G-protein-coupled receptor) (G-protein coupled receptor 126) (Vascular inducible G protein-coupled receptor) [Cleaved into: ADGRG6 N-terminal fragment (ADGRG6-NTF); ADGRG6 C-terminal fragment (ADGRG6-CTF)]
1_MMFRS 6_ DRMWS 11_ CHWKW 16_ KPSPL 21_ LFLFA 26_ LYIMC 31_ VPHSV 36_ WGCAN 41_ CRVVL 46_ SNPSG 51_ TFTSP 56_ CYPND 61_ YPNSQ 66_ ACMWT 71_ LRAPT 76_ GYIIQ 81_ ITFND 86_ FDIEE 91_ APNCI 96_ YDSLS 101_ LDNGE 106_ SQTKF 111_ CGATA 116_ KGLSF 121_ NSSAN 126_ EMHVS 131_ FSSDF 136_ SIQKK 141_ GFNAS 146_ YIRVA 151_ VSLRN 156_ QKVIL 161_ PQTSD 166_ AYQVS 171_ VAKSI 176_ SIPEL 181_ SAFTL 186_ CFEAT 191_ KVGHE 196_ DSDWT 201_ AFSYS 206_ NASFT 211_ QLLSF 216_ GKAKS 221_ GYFLS 226_ ISDSK 231_ CLLNN 236_ ALPVK 241_ EKEDI 246_ FAESF 251_ EQLCL 256_ VWNNS 261_ LGSIG 266_ VNFKR 271_ NYETV 276_ PCDST 281_ ISKVI 286_ PGNGK 291_ LLLGS 296_ NQNEI 301_ VSLKG 306_ DIYNF 311_ RLWNF 316_ TMNAK 321_ ILSNL 326_ SCNVK 331_ GNVVD 336_ WQNDF 341_ WNIPN 346_ LALKA 351_ ESNLS 356_ CGSYL 361_ IPLPA 366_ AELAS 371_ CADLG 376_ TLCQA 381_ TVNSP 386_ STTPP 391_ TVTTN 396_ MPVTN 401_ RIDKQ 406_ RNDGI 411_ IYRIS 416_ VVIQN 421_ ILRHP 426_ EVKVQ 431_ SKVAE 436_ WLNST 441_ FQNWN 446_ YTVYV 451_ VNISF 456_ HLSAG 461_ EDKIK 466_ VKRSL 471_ EDEPR 476_ LVLWA 481_ LLVYN 486_ ATNNT 491_ NLEGK 496_ IIQQK 501_ LLKNN 506_ ESLDE 511_ GLRLH 516_ TVNVR 521_ QLGHC 526_ LAMEE 531_ PKGYY 536_ WPSIQ 541_ PSEYV 546_ LPCPD 551_ KPGFS 556_ ASRIC 561_ FYNAT 566_ NPLVT 571_ YWGPV 576_ DISNC 581_ LKEAN 586_ EVANQ 591_ ILNLT 596_ ADGQN 601_ LTSAN 606_ ITNIV 611_ EQVKR 616_ IVNKE 621_ ENIDI 626_ TLGST 631_ LMNIF 636_ SNILS 641_ SSDSD 646_ LLESS 651_ SEALK 656_ TIDEL 661_ AFKID 666_ LNSTS 671_ HVNIT 676_ TRNLA 681_ LSVSS 686_ LLPGT 691_ NAISN 696_ FSIGL 701_ PSNNE 706_ SYFQM 711_ DFESG 716_ QVDPL 721_ ASVIL 726_ PPNLL 731_ ENLSP 736_ EDSVL 741_ VRRAQ 746_ FTFFN 751_ KTGLF 756_ QDVGP 761_ QRKTL 766_ VSYVM 771_ ACSIG 776_ NITIQ 781_ NLKDP 786_ VQIKI 791_ KHTRT 796_ QEVHH 801_ PICAF 806_ WDLNK 811_ NKSFG 816_ GWNTS 821_ GCVAH 826_ RDSDA 831_ SETVC 836_ LCNHF 841_ THFGV 846_ LMDLP 851_ RSASQ 856_ LDARN 861_ TKVLT 866_ FISYI 871_ GCGIS 876_ AIFSA 881_ ATLLT 886_ YVAFE 891_ KLRRD 896_ YPSKI 901_ LMNLS 906_ TALLF 911_ LNLLF 916_ LLDGW 921_ ITSFN 926_ VDGLC 931_ IAVAV 936_ LLHFF 941_ LLATF 946_ TWMGL 951_ EAIHM 956_ YIALV 961_ KVFNT 966_ YIRRY 971_ ILKFC 976_ IIGWG 981_ LPALV 986_ VSVVL 991_ ASRNN 996_ NEVYG 1001_ KESYG 1006_ KEKGD 1011_ EFCWI 1016_ QDPVI 1021_ FYVTC 1026_ AGYFG 1031_ VMFFL 1036_ NIAMF 1041_ IVVMV 1046_ QICGR 1051_ NGKRS 1056_ NRTLR 1061_ EEVLR 1066_ NLRSV 1071_ VSLTF 1076_ LLGMT 1081_ WGFAF 1086_ FAWGP 1091_ LNIPF 1096_ MYLFS 1101_ IFNSL 1106_ QGLFI 1111_ FIFHC 1116_ AMKEN 1121_ VQKQW 1126_ RQHLC 1131_ CGRFR 1136_ LADNS 1141_ DWSKT 1146_ ATNII 1151_ KKSSD 1156_ NLGKS 1161_ LSSSS 1166_ IGSNS 1171_ TYLTS 1176_ KSKSS 1181_ STTYF 1186_ KRNSH 1191_ TDNVS 1196_ YEHSF 1201_ NKSGS 1206_ LRQCF 1211_ HGQVL 1216_VKTGP
1: Adhesion G-protein coupled receptor (aGPCR) for steroid hormones, such as progesterone and 17alpha-hydroxyprogesterone (17OHP) (PubMed:35394864, PubMed:39884271). Involved in many biological processes, such as myelination, sprouting angiogenesis, placenta, ear and cartilage development (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:24227709, PubMed:35394864). ADGRG6 is coupled to G(i) G alpha proteins and mediates inhibition of adenylate cyclase (PubMed:24227709, PubMed:35394864). Also able to couple to G(q) G proteins (PubMed:24227709). Involved in myelination of the peripheral nervous system: required for differentiation of promyelinating Schwann cells and for normal myelination of axons (PubMed:24227709). Also acts as a regulator of body length and bone mass (PubMed:18391950). Acts as a regulator of blood-brain barrier formation in the central nervous system vie its association with LRP1 and ITGB1 (By similarity)