Dehydrodolichyl diphosphate synthase complex subunit DHDDS (EC 2.5.1.87) (Cis-isoprenyltransferase) (CIT) (Cis-IPTase) (Cis-prenyltransferase subunit hCIT) (Epididymis tissue protein Li 189m)
1_MSWIK 6_ EGELS 11_ LWERF 16_ CANII 21_ KAGPM 26_ PKHIA 31_ FIMDG 36_ NRRYA 41_ KKCQV 46_ ERQEG 51_ HSQGF 56_ NKLAE 61_ TLRWC 66_ LNLGI 71_ LEVTV 76_ YAFSI 81_ ENFKR 86_ SKSEV 91_ DGLMD 96_ LARQK 101_ FSRLM 106_ EEKEK 111_ LQKHG 116_ VCIRV 121_ LGDLH 126_ LLPLD 131_ LQELI 136_ AQAVQ 141_ ATKNY 146_ NKCFL 151_ NVCFA 156_ YTSRH 161_ EISNA 166_ VREMA 171_ WGVEQ 176_ GLLDP 181_ SDISE 186_ SLLDK 191_ CLYTN 196_ RSPHP 201_ DILIR 206_ TSGEV 211_ RLSDF 216_ LLWQT 221_ SHSCL 226_ VFQPV 231_ LWPEY 236_ TFWNL 241_ FEAIL 246_ QFQMN 251_ HSVLQ 256_ KARDM 261_ YAEER 266_ KRQQL 271_ ERDQA 276_ TVTEQ 281_ LLREG 286_ LQASG 291_ DAQLR 296_ RTRLH 301_ KLSAR 306_ REERV 311_ QGFLQ 316_ ALELK 321_ RADWL 326_ARLGT
1: With NUS1, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery (PubMed:25066056, PubMed:28842490, PubMed:32817466, PubMed:33077723). Both subunits contribute to enzymatic activity, i.e. condensation of multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol phosphate which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER) (PubMed:25066056, PubMed:28842490, PubMed:32817466, PubMed:33077723). Synthesizes long-chain polyprenols, mostly of C95 and C100 chain length (PubMed:32817466). Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol (PubMed:21572394)