Immunoglobulin-like domain-containing receptor 1 (Angulin-2)
1_MAWPK 6_ LPAPW 11_ LLLCT 16_ WLPAG 21_ CLSLL 26_ VTVQH 31_ TERYV 36_ TLFAS 41_ IILKC 46_ DYTTS 51_ AQLQD 56_ VVVTW 61_ RFKSF 66_ CKDPI 71_ FDYYS 76_ ASYQA 81_ ALSLG 86_ QDPSN 91_ DCNDN 96_ QREVR 101_ IVAQR 106_ RGQNE 111_ PVLGV 116_ DYRQR 121_ KITIQ 126_ NRADL 131_ VINEV 136_ MWWDH 141_ GVYYC 146_ TIEAP 151_ GDTSG 156_ DPDKE 161_ VKLIV 166_ LHWLT 171_ VIFII 176_ LGALL 181_ LLLLI 186_ GVCWC 191_ QCCPQ 196_ YCCCY 201_ IRCPC 206_ CPAHC 211_ CCPEE 216_ ALARH 221_ RYMKQ 226_ AQALG 231_ PQMMG 236_ KPLYW 241_ GADRS 246_ SQVSS 251_ YPMHP 256_ LLQRD 261_ LSLPS 266_ SLPQM 271_ PMTQT 276_ TNQPP 281_ IANGV 286_ LEYLE 291_ KELRN 296_ LNLAQ 301_ PLPPD 306_ LKGRF 311_ GHPCS 316_ MLSSL 321_ GSEVV 326_ ERRII 331_ HLPPL 336_ IRDLS 341_ SSRRT 346_ SDSLH 351_ QQWLT 356_ PIPSR 361_ PWDLR 366_ EGRSH 371_ HHYPD 376_ FHQEL 381_ QDRGP 386_ KSWAL 391_ ERREL 396_ DPSWS 401_ GRHRS 406_ SRLNG 411_ SPIHW 416_ SDRDS 421_ LSDVP 426_ SSSEA 431_ RWRPS 436_ HPPFR 441_ SRCQE 446_ RPRRP 451_ SPRES 456_ TQRHG 461_ RRRRH 466_ RSYSP 471_ PLPSG 476_ LSSWS 481_ SEEDK 486_ ERQPQ 491_ SWRAH 496_ RRGSH 501_ SPHWP 506_ EEKPP 511_ SYRSL 516_ DITPG 521_ KNSRK 526_ KGSVE 531_ RRSEK 536_ DSSHS 541_GRSVV
1: Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions (tTJs) (PubMed:23239027). Crucial for normal hearing by maintaining the structural and functional integrity of tTJs, which are critical for the survival of auditory neurosensory HCs. Mediates fatty acids and lipoproteins-stimulated CCK/cholecystokinin secretion in the small intestine. In the inner ear, may regulate alternative pre-mRNA splicing via binding to TRA2A, TRA2B and SRSF1 (By similarity)
2: (Microbial infection) Promotes influenza virus infection by inhibiting viral nucleoprotein NP binding to PLSCR1 and thereby PLSCR1-mediated antiviral activity