Gene name: GLRX5

Uniprot entry:

Q86SX6

Protein names:

Glutaredoxin-related protein 5, mitochondrial (Monothiol glutaredoxin-5)

Protein sequence:

1_MSGSL 6_ GRAAA 11_ ALLRW 16_ GRGAG 21_ GGGLW 26_ GPGVR 31_ AAGSG 36_ AGGGG 41_ SAEQL 46_ DALVK 51_ KDKVV 56_ VFLKG 61_ TPEQP 66_ QCGFS 71_ NAVVQ 76_ ILRLH 81_ GVRDY 86_ AAYNV 91_ LDDPE 96_ LRQGI 101_ KDYSN 106_ WPTIP 111_ QVYLN 116_ GEFVG 121_ GCDIL 126_ LQMHQ 131_ NGDLV 136_ EELKK 141_ LGIHS 146_ ALLDE 151_KKDQD

Protein annotations

Protein functions:

1: Monothiol glutaredoxin involved in mitochondrial iron-sulfur (Fe/S) cluster transfer (PubMed:20364084, PubMed:23615440). Receives 2Fe/2S clusters from scaffold protein ISCU and mediates their transfer to apoproteins, to the 4Fe/FS cluster biosynthesis machinery, or export from mitochondrion (PubMed:20364084, PubMed:23615440, PubMed:24334290). Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1 (PubMed:20364084)