Transcriptional regulator Kaiso (Zinc finger and BTB domain-containing protein 33)
1_MESRK 6_ LISAT 11_ DIQYS 16_ GSLLN 21_ SLNEQ 26_ RGHGL 31_ FCDVT 36_ VIVED 41_ RKFRA 46_ HKNIL 51_ SASST 56_ YFHQL 61_ FSVAG 66_ QVVEL 71_ SFIRA 76_ EIFAE 81_ ILNYI 86_ YSSKI 91_ VRVRS 96_ DLLDE 101_ LIKSG 106_ QLLGV 111_ KFIAE 116_ LGVPL 121_ SQVKS 126_ ISGTA 131_ QDGNT 136_ EPLPP 141_ DSGDK 146_ NLVIQ 151_ KSKDE 156_ AQDNG 161_ ATIMP 166_ IITES 171_ FSLSA 176_ EDYEM 181_ KKIIV 186_ TDSDD 191_ DDDDV 196_ IFCSE 201_ ILPTK 206_ ETLPS 211_ NNTVA 216_ QVQSN 221_ PGPVA 226_ ISDVA 231_ PSASN 236_ NSPPL 241_ TNITP 246_ TQKLP 251_ TPVNQ 256_ ATLSQ 261_ TQGSE 266_ KLLVS 271_ SAPTH 276_ LTPNI 281_ ILLNQ 286_ TPLST 291_ PPNVS 296_ SSLPN 301_ HMPSS 306_ INLLV 311_ QNQQT 316_ PNSAI 321_ LTGNK 326_ ANEEE 331_ EEEII 336_ DDDDD 341_ TISSS 346_ PDSAV 351_ SNTSL 356_ VPQAD 361_ TSQNT 366_ SFDGS 371_ LIQKM 376_ QIPTL 381_ LQEPL 386_ SNSLK 391_ ISDII 396_ TRNTN 401_ DPGVG 406_ SKHLM 411_ EGQKI 416_ ITLDT 421_ ATEIE 426_ GLSTG 431_ CKVYA 436_ NIGED 441_ TYDIV 446_ IPVKD 451_ DPDEG 456_ EARLE 461_ NEIPK 466_ TSGSE 471_ MANKR 476_ MKVKH 481_ DDHYE 486_ LIVDG 491_ RVYYI 496_ CIVCK 501_ RSYVC 506_ LTSLR 511_ RHFNI 516_ HSWEK 521_ KYPCR 526_ YCEKV 531_ FPLAE 536_ YRTKH 541_ EIHHT 546_ GERRY 551_ QCLAC 556_ GKSFI 561_ NYQFM 566_ SSHIK 571_ SVHSQ 576_ DPSGD 581_ SKLYR 586_ LHPCR 591_ SLQIR 596_ QYAYL 601_ SDRSS 606_ TIPAM 611_ KDDGI 616_ GYKVD 621_ TGKEP 626_ PVGTT 631_ TSTQN 636_ KPMTW 641_ EDIFI 646_ QQEND 651_ SIFKQ 656_ NVTDG 661_ STEFE 666_FIIPE
1: Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. May contribute to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2. Represses expression of MMP7 in conjunction with transcriptional corepressors CBFA2T3, CBFA2T2 and RUNX1T1 (PubMed:23251453)