Disheveled-associated activator of morphogenesis 2
1_MAPRK 6_ RSHHG 11_ LGFLC 16_ CFGGS 21_ DIPEI 26_ NLRDN 31_ HPLQF 36_ MEFSS 41_ PIPNA 46_ EELNI 51_ RFAEL 56_ VDELD 61_ LTDKN 66_ REAMF 71_ ALPPE 76_ KKWQI 81_ YCSKK 86_ KEQED 91_ PNKLA 96_ TSWPD 101_ YYIDR 106_ INSMA 111_ AMQSL 116_ YAFDE 121_ EETEM 126_ RNQVV 131_ EDLKT 136_ ALRTQ 141_ PMRFV 146_ TRFIE 151_ LEGLT 156_ CLLNF 161_ LRSMD 166_ HATCE 171_ SRIHT 176_ SLIGC 181_ IKALM 186_ NNSQG 191_ RAHVL 196_ AQPEA 201_ ISTIA 206_ QSLRT 211_ ENSKT 216_ KVAVL 221_ EILGA 226_ VCLVP 231_ GGHKK 236_ VLQAM 241_ LHYQV 246_ YAAER 251_ TRFQT 256_ LLNEL 261_ DRSLG 266_ RYRDE 271_ VNLKT 276_ AIMSF 281_ INAVL 286_ NAGAG 291_ EDNLE 296_ FRLHL 301_ RYEFL 306_ MLGIQ 311_ PVIDK 316_ LRQHE 321_ NAILD 326_ KHLDF 331_ FEMVR 336_ NEDDL 341_ ELARR 346_ FDMVH 351_ IDTKS 356_ ASQMF 361_ ELIHK 366_ KLKYT 371_ EAYPC 376_ LLSVL 381_ HHCLQ 386_ MPYKR 391_ NGGYF 396_ QQWQL 401_ LDRIL 406_ QQIVL 411_ QDERG 416_ VDPDL 421_ APLEN 426_ FNVKN 431_ IVNML 436_ INENE 441_ VKQWR 446_ DQAEK 451_ FRKEH 456_ MELVS 461_ RLERK 466_ ERECE 471_ TKTLE 476_ KEEMM 481_ RTLNK 486_ MKDKL 491_ ARESQ 496_ ELRQA 501_ RGQVA 506_ ELVAQ 511_ LSELS 516_ TGPVS 521_ SPPPP 526_ GGPLT 531_ LSSSM 536_ TTNDL 541_ PPPPP 546_ PLPFA 551_ CCPPP 556_ PPPPL 561_ PPGGP 566_ PTPPG 571_ APPCL 576_ GMGLP 581_ LPQDP 586_ YPSSD 591_ VPLRK 596_ KRVPQ 601_ PSHPL 606_ KSFNW 611_ VKLNE 616_ ERVPG 621_ TVWNE 626_ IDDMQ 631_ VFRIL 636_ DLEDF 641_ EKMFS 646_ AYQRH 651_ QKELG 656_ STEDI 661_ YLASR 666_ KVKEL 671_ SVIDG 676_ RRAQN 681_ CIILL 686_ SKLKL 691_ SNEEI 696_ RQAIL 701_ KMDEQ 706_ EDLAK 711_ DMLEQ 716_ LLKFI 721_ PEKSD 726_ IDLLE 731_ EHKHE 736_ IERMA 741_ RADRF 746_ LYEMS 751_ RIDHY 756_ QQRLQ 761_ ALFFK 766_ KKFQE 771_ RLAEA 776_ KPKVE 781_ AILLA 786_ SRELV 791_ RSKRL 796_ RQMLE 801_ VILAI 806_ GNFMN 811_ KGQRG 816_ GAYGF 821_ RVASL 826_ NKIAD 831_ TKSSI 836_ DRNIS 841_ LLHYL 846_ IMILE 851_ KHFPD 856_ ILNMP 861_ SELQH 866_ LPEAA 871_ KVNLA 876_ ELEKE 881_ VGNLR 886_ RGLRA 891_ VEVEL 896_ EYQRR 901_ QVREP 906_ SDKFV 911_ PVMSD 916_ FITVS 921_ SFSFS 926_ ELEDQ 931_ LNEAR 936_ DKFAK 941_ ALMHF 946_ GEHDS 951_ KMQPD 956_ EFFGI 961_ FDTFL 966_ QAFSE 971_ ARQDL 976_ EAMRR 981_ RKEEE 986_ ERRAR 991_ MEAML 996_ KEQRE 1001_ RERWQ 1006_ RQRKV 1011_ LAAGS 1016_ SLEEG 1021_ GEFDD 1026_ LVSAL 1031_ RSGEV 1036_ FDKDL 1041_ CKLKR 1046_ SRKRS 1051_ GSQAL 1056_ EVTRE 1061_RAINR
1: Key regulator of the Wnt signaling pathway, which is required for various processes during development, such as dorsal patterning, determination of left/right symmetry or myelination in the central nervous system. Acts downstream of Wnt ligands and upstream of beta-catenin (CTNNB1). Required for canonical Wnt signaling pathway during patterning in the dorsal spinal cord by promoting the aggregation of Disheveled (Dvl) complexes, thereby clustering and formation of Wnt receptor signalosomes and potentiating Wnt activity. During dorsal patterning of the spinal cord, inhibits oligodendrocytes differentiation via interaction with PIP5K1A. Also regulates non-canonical Wnt signaling pathway. Acts downstream of PITX2 in the developing gut and is required for left/right asymmetry within dorsal mesentery: affects mesenchymal condensation by lengthening cadherin-based junctions through WNT5A and non-canonical Wnt signaling, inducing polarized condensation in the left dorsal mesentery necessary to initiate gut rotation. Together with DAAM1, required for myocardial maturation and sarcomere assembly. Is a regulator of actin nucleation and elongation, filopodia formation and podocyte migration (PubMed:33232676)