Ubiquitin carboxyl-terminal hydrolase 37 (EC 3.4.19.12) (Deubiquitinating enzyme 37) (Ubiquitin thioesterase 37) (Ubiquitin-specific-processing protease 37)
1_MSPLK 6_ IHGPI 11_ RIRSM 16_ QTGIT 21_ KWKEG 26_ SFEIV 31_ EKENK 36_ VSLVV 41_ HYNTG 46_ GIPRI 51_ FQLSH 56_ NIKNV 61_ VLRPS 66_ GAKQS 71_ RLMLT 76_ LQDNS 81_ FLSID 86_ KVPSK 91_ DAEEM 96_ RLFLD 101_ AVHQN 106_ RLPAA 111_ MKPSQ 116_ GSGSF 121_ GAILG 126_ SRTSQ 131_ KETSR 136_ QLSYS 141_ DNQAS 146_ AKRGS 151_ LETKD 156_ DIPFR 161_ KVLGN 166_ PGRGS 171_ IKTVA 176_ GSGIA 181_ RTIPS 186_ LTSTS 191_ TPLRS 196_ GLLEN 201_ RTEKR 206_ KRMIS 211_ TGSEL 216_ NEDYP 221_ KENDS 226_ SSNNK 231_ AMTDP 236_ SRKYL 241_ TSSRE 246_ KQLSL 251_ KQSEE 256_ NRTSG 261_ LLPLQ 266_ SSSFY 271_ GSRAG 276_ SKEHS 281_ SGGTN 286_ LDRTN 291_ VSSQT 296_ PSAKR 301_ SLGFL 306_ PQPVP 311_ LSVKK 316_ LRCNQ 321_ DYTGW 326_ NKPRV 331_ PLSSH 336_ QQQQL 341_ QGFSN 346_ LGNTC 351_ YMNAI 356_ LQSLF 361_ SLQSF 366_ ANDLL 371_ KQGIP 376_ WKKIP 381_ LNALI 386_ RRFAH 391_ LLVKK 396_ DICNS 401_ ETKKD 406_ LLKKV 411_ KNAIS 416_ ATAER 421_ FSGYM 426_ QNDAH 431_ EFLSQ 436_ CLDQL 441_ KEDME 446_ KLNKT 451_ WKTEP 456_ VSGEE 461_ NSPDI 466_ SATRA 471_ YTCPV 476_ ITNLE 481_ FEVQH 486_ SIICK 491_ ACGEI 496_ IPKRE 501_ QFNDL 506_ SIDLP 511_ RRKKP 516_ LPPRS 521_ IQDSL 526_ DLFFR 531_ AEELE 536_ YSCEK 541_ CGGKC 546_ ALVRH 551_ KFNRL 556_ PRVLI 561_ LHLKR 566_ YSFNV 571_ ALSLN 576_ NKIGQ 581_ QVIIP 586_ RYLTL 591_ SSHCT 596_ ENTKP 601_ PFTLG 606_ WSAHM 611_ AISRP 616_ LKASQ 621_ MVNSC 626_ ITSPS 631_ TPSKK 636_ FTFKS 641_ KSSLA 646_ LCLDS 651_ DSEDE 656_ LKRSV 661_ ALSQR 666_ LCEML 671_ GNEQQ 676_ QEDLE 681_ KDSKL 686_ CPIEP 691_ DKSEL 696_ ENSGF 701_ DRMSE 706_ EELLA 711_ AVLEI 716_ SKRDA 721_ SPSLS 726_ HEDDD 731_ KPTSS 736_ PDTGF 741_ AEDDI 746_ QEMPE 751_ NPDTM 756_ ETEKP 761_ KTITE 766_ LDPAS 771_ FTEIT 776_ KDCDE 781_ NKENK 786_ TPEGS 791_ QGEVD 796_ WLQQY 801_ DMERE 806_ REEQE 811_ LQQAL 816_ AQSLQ 821_ EQEAW 826_ EQKED 831_ DDLKR 836_ ATELS 841_ LQEFN 846_ NSFVD 851_ ALGSD 856_ EDSGN 861_ EDVFD 866_ MEYTE 871_ AEAEE 876_ LKRNA 881_ ETGNL 886_ PHSYR 891_ LISVV 896_ SHIGS 901_ TSSSG 906_ HYISD 911_ VYDIK 916_ KQAWF 921_ TYNDL 926_ EVSKI 931_ QEAAV 936_ QSDRD 941_ RSGYI 946_ FFYMH 951_ KEIFD 956_ ELLET 961_ EKNSQ 966_ SLSTE 971_VGKTT
1: Deubiquitinase that plays a role in different processes including cell cycle regulation, DNA replication or DNA damage response (PubMed:26299517, PubMed:27296872, PubMed:31911859, PubMed:34509474). Antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2) (PubMed:21596315). Plays an important role in the regulation of DNA replication by stabilizing the licensing factor CDT1 (PubMed:27296872). Also plays an essential role beyond S-phase entry to promote the efficiency and fidelity of replication by deubiquitinating checkpoint kinase 1/CHK1, promoting its stability (PubMed:34509474). Sustains the DNA damage response (DDR) by deubiquitinating and stabilizing the ATP-dependent DNA helicase BLM (PubMed:34606619). Mechanistically, DNA double-strand breaks (DSB) promotes ATM-mediated phosphorylation of USP37 and enhances the binding between USP37 and BLM (PubMed:34606619). Promotes cell migration by deubiquitinating and stabilizing the epithelial-mesenchymal transition (EMT)-inducing transcription factor SNAI (PubMed:31911859). Plays a role in the regulation of mitotic spindle assembly and mitotic progression by associating with chromatin-associated WAPL and stabilizing it through deubiquitination (PubMed:26299517)