Retrotransposon-derived protein PEG10 (Embryonal carcinoma differentiation-regulated protein) (Mammalian retrotransposon-derived protein 2) (Myelin expression factor 3-like protein 1) (MEF3-like protein 1) (Paternally expressed gene 10 protein) (Retrotransposon gag domain-containing protein 3) (Retrotransposon-derived gag-like polyprotein) (Ty3/Gypsy-like protein)
1_MTERR 6_ RDELS 11_ EEINN 16_ LREKV 21_ MKQSE 26_ ENNNL 31_ QSQVQ 36_ KLTEE 41_ NTTLR 46_ EQVEP 51_ TPEDE 56_ DDDIE 61_ LRGAA 66_ AAAAP 71_ PPPIE 76_ EECPE 81_ DLPEK 86_ FDGNP 91_ DMLAP 96_ FMAQC 101_ QIFME 106_ KSTRD 111_ FSVDR 116_ VRVCF 121_ VTSMM 126_ TGRAA 131_ RWASA 136_ KLERS 141_ HYLMH 146_ NYPAF 151_ MMEMK 156_ HVFED 161_ PQRRE 166_ VAKRK 171_ IRRLR 176_ QGMGS 181_ VIDYS 186_ NAFQM 191_ IAQDL 196_ DWNEP 201_ ALIDQ 206_ YHEGL 211_ SDHIQ 216_ EELSH 221_ LEVAK 226_ SLSAL 231_ IGQCI 236_ HIERR 241_ LARAA 246_ AARKP 251_ RSPPR 256_ ALVLP 261_ HIASH 266_ HQVDP 271_ TEPVG 276_ GARMR 281_ LTQEE 286_ KERRR 291_ KLNLC 296_ LYCGT 301_ GGHYA 306_ DNCPA 311_ KASKS 316_ SPAGK 321_ LPGPA 326_ VEGPS 331_ ATGPE 336_ IIRSP 341_ QDDAS 346_ SPHLQ 351_ VMLQI 356_ HLPGR 361_ HTLFV 366_ RAMID 371_ SGASG 376_ NFIDH 381_ EYVAQ 386_ NGIPL 391_ RIKDW 396_ PILVE 401_ AIDGR 406_ PIASG 411_ PVVHE 416_ THDLI 421_ VDLGD 426_ HREVL 431_ SFDVT 436_ QSPFF 441_ PVVLG 446_ VRWLS 451_ THDPN 456_ ITWST 461_ RSIVF 466_ DSEYC 471_ RYHCR 476_ MYSPI 481_ PPSLP 486_ PPAPQ 491_ PPLYY 496_ PVDGY 501_ RVYQP 506_ VRYYY 511_ VQNVY 516_ TPVDE 521_ HVYPD 526_ HRLVD 531_ PHIEM 536_ IPGAH 541_ SIPSG 546_ HVYSL 551_ SEPEM 556_ AALRD 561_ FVARN 566_ VKDGL 571_ ITPTI 576_ APNGA 581_ QVLQV 586_ KRGWK 591_ LQVSY 596_ DCRAP 601_ NNFTI 606_ QNQYP 611_ RLSIP 616_ NLEDQ 621_ AHLAT 626_ YTEFV 631_ PQIPG 636_ YQTYP 641_ TYAAY 646_ PTYPV 651_ GFAWY 656_ PVGRD 661_ GQGRS 666_ LYVPV 671_ MITWN 676_ PHWYR 681_ QPPVP 686_ QYPPP 691_ QPPPP 696_ PPPPP 701_PPPSY
1: Retrotransposon-derived protein that binds its own mRNA and self-assembles into virion-like capsids (PubMed:34413232). Forms virion-like extracellular vesicles that encapsulate their own mRNA and are released from cells, enabling intercellular transfer of PEG10 mRNA (PubMed:34413232). Binds its own mRNA in the 5'-UTR region, in the region near the boundary between the nucleocapsid (NC) and protease (PRO) coding sequences and in the beginning of the 3'-UTR region (PubMed:34413232). Involved in placenta formation: required for trophoblast stem cells differentiation (By similarity). Involved at the immediate early stage of adipocyte differentiation (By similarity). Overexpressed in many cancers and enhances tumor progression: promotes cell proliferation by driving cell cycle progression from G0/G1 (PubMed:12810624, PubMed:16423995, PubMed:26235627, PubMed:28193232). Enhances cancer progression by inhibiting the TGF-beta signaling, possibly via interaction with the TGF-beta receptor ACVRL1 (PubMed:15611116, PubMed:26235627, PubMed:30094509). May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter; additional evidences are however required to confirm this result (By similarity)