Dipeptidyl peptidase 9 (DP9) (EC 3.4.14.5) (Dipeptidyl peptidase IV-related protein 2) (DPRP-2) (Dipeptidyl peptidase IX) (DPP IX) (Dipeptidyl peptidase-like protein 9) (DPLP9)
1_MATTG 6_ TPTAD 11_ RGDAA 16_ ATDDP 21_ AARFQ 26_ VQKHS 31_ WDGLR 36_ SIIHG 41_ SRKYS 46_ GLIVN 51_ KAPHD 56_ FQFVQ 61_ KTDES 66_ GPHSH 71_ RLYYL 76_ GMPYG 81_ SRENS 86_ LLYSE 91_ IPKKV 96_ RKEAL 101_ LLLSW 106_ KQMLD 111_ HFQAT 116_ PHHGV 121_ YSREE 126_ ELLRE 131_ RKRLG 136_ VFGIT 141_ SYDFH 146_ SESGL 151_ FLFQA 156_ SNSLF 161_ HCRDG 166_ GKNGF 171_ MVSPM 176_ KPLEI 181_ KTQCS 186_ GPRMD 191_ PKICP 196_ ADPAF 201_ FSFIN 206_ NSDLW 211_ VANIE 216_ TGEER 221_ RLTFC 226_ HQGLS 231_ NVLDD 236_ PKSAG 241_ VATFV 246_ IQEEF 251_ DRFTG 256_ YWWCP 261_ TASWE 266_ GSEGL 271_ KTLRI 276_ LYEEV 281_ DESEV 286_ EVIHV 291_ PSPAL 296_ EERKT 301_ DSYRY 306_ PRTGS 311_ KNPKI 316_ ALKLA 321_ EFQTD 326_ SQGKI 331_ VSTQE 336_ KELVQ 341_ PFSSL 346_ FPKVE 351_ YIARA 356_ GWTRD 361_ GKYAW 366_ AMFLD 371_ RPQQW 376_ LQLVL 381_ LPPAL 386_ FIPST 391_ ENEEQ 396_ RLASA 401_ RAVPR 406_ NVQPY 411_ VVYEE 416_ VTNVW 421_ INVHD 426_ IFYPF 431_ PQSEG 436_ EDELC 441_ FLRAN 446_ ECKTG 451_ FCHLY 456_ KVTAV 461_ LKSQG 466_ YDWSE 471_ PFSPG 476_ EDEFK 481_ CPIKE 486_ EIALT 491_ SGEWE 496_ VLARH 501_ GSKIW 506_ VNEET 511_ KLVYF 516_ QGTKD 521_ TPLEH 526_ HLYVV 531_ SYEAA 536_ GEIVR 541_ LTTPG 546_ FSHSC 551_ SMSQN 556_ FDMFV 561_ SHYSS 566_ VSTPP 571_ CVHVY 576_ KLSGP 581_ DDDPL 586_ HKQPR 591_ FWASM 596_ MEAAS 601_ CPPDY 606_ VPPEI 611_ FHFHT 616_ RSDVR 621_ LYGMI 626_ YKPHA 631_ LQPGK 636_ KHPTV 641_ LFVYG 646_ GPQVQ 651_ LVNNS 656_ FKGIK 661_ YLRLN 666_ TLASL 671_ GYAVV 676_ VIDGR 681_ GSCQR 686_ GLRFE 691_ GALKN 696_ QMGQV 701_ EIEDQ 706_ VEGLQ 711_ FVAEK 716_ YGFID 721_ LSRVA 726_ IHGWS 731_ YGGFL 736_ SLMGL 741_ IHKPQ 746_ VFKVA 751_ IAGAP 756_ VTVWM 761_ AYDTG 766_ YTERY 771_ MDVPE 776_ NNQHG 781_ YEAGS 786_ VALHV 791_ EKLPN 796_ EPNRL 801_ LILHG 806_ FLDEN 811_ VHFFH 816_ TNFLV 821_ SQLIR 826_ AGKPY 831_ QLQIY 836_ PNERH 841_ SIRCP 846_ ESGEH 851_ YEVTL 856_LHFLQ
1: Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2 (PubMed:12662155, PubMed:16475979, PubMed:19667070, PubMed:29382749, PubMed:30291141, PubMed:33731929, PubMed:36112693). Acts as a key inhibitor of caspase-1-dependent monocyte and macrophage pyroptosis in resting cells by preventing activation of NLRP1 and CARD8 (PubMed:27820798, PubMed:29967349, PubMed:30291141, PubMed:31525884, PubMed:32796818, PubMed:36112693, PubMed:36357533). Sequesters the cleaved C-terminal part of NLRP1 and CARD8, which respectively constitute the active part of the NLRP1 and CARD8 inflammasomes, in a ternary complex, thereby preventing their oligomerization and activation (PubMed:33731929, PubMed:33731932, PubMed:34019797). The dipeptidyl peptidase activity is required to suppress NLRP1 and CARD8; however, neither NLRP1 nor CARD8 are bona fide substrates of DPP9, suggesting the existence of substrate(s) required for NLRP1 and CARD8 inhibition (PubMed:33731929)