Store-operated calcium entry regulator STIMATE (STIM-activating enhancer encoded by TMEM110) (Transmembrane protein 110)
1_MQGPA 6_ GNASR 11_ GLPGG 16_ PPSTV 21_ ASGAG 26_ RCESG 31_ ALMHS 36_ FGIFL 41_ QGLLG 46_ VVAFS 51_ TLMLK 56_ RFREP 61_ KHERR 66_ PWRIW 71_ FLDTS 76_ KQAIG 81_ MLFIH 86_ FANVY 91_ LADLT 96_ EEDPC 101_ SLYLI 106_ NFLLD 111_ ATVGM 116_ LLIYV 121_ GVRAV 126_ SVLVE 131_ WQQWE 136_ SLRFG 141_ EYGDP 146_ LQCGA 151_ WVGQC 156_ ALYIV 161_ IMIFE 166_ KSVVF 171_ IVLLI 176_ LQWKK 181_ VALLN 186_ PIENP 191_ DLKLA 196_ IVMLI 201_ VPFFV 206_ NALMF 211_ WVVDN 216_ FLMRK 221_ GKTKA 226_ KLEER 231_ GANQD 236_ SRNGS 241_ KVRYR 246_ RAASH 251_ EESES 256_ EILIS 261_ ADDEM 266_ EESDV 271_ EEDLR 276_ RLTPL 281_ KPVKK 286_KKHRF
1: Acts as a regulator of store-operated Ca(2+) entry (SOCE) at junctional sites that connect the endoplasmic reticulum (ER) and plasma membrane (PM), called ER-plasma membrane (ER-PM) junction or cortical ER (PubMed:26322679, PubMed:26644574). SOCE is a Ca(2+) influx following depletion of intracellular Ca(2+) stores (PubMed:26322679). Acts by interacting with STIM1, promoting STIM1 conformational switch (PubMed:26322679). Involved in STIM1 relocalization to ER-PM junctions (PubMed:26644574). Contributes to the maintenance and reorganization of store-dependent ER-PM junctions (PubMed:26644574)