Exopolyphosphatase PRUNE1 (EC 3.6.1.1) (Drosophila-related expressed sequence 17) (DRES-17) (DRES17) (HTcD37) (Protein prune homolog 1) (hPrune)
1_MEDYL 6_ QGCRA 11_ ALQES 16_ RPLHV 21_ VLGNE 26_ ACDLD 31_ STVSA 36_ LALAF 41_ YLAKT 46_ TEAEE 51_ VFVPV 56_ LNIKR 61_ SELPL 66_ RGDIV 71_ FFLQK 76_ VHIPE 81_ SILIF 86_ RDEID 91_ LHALY 96_ QAGQL 101_ TLILV 106_ DHHIL 111_ SKSDT 116_ ALEEA 121_ VAEVL 126_ DHRPI 131_ EPKHC 136_ PPCHV 141_ SVELV 146_ GSCAT 151_ LVTER 156_ ILQGA 161_ PEILD 166_ RQTAA 171_ LLHGT 176_ IILDC 181_ VNMDL 186_ KIGKA 191_ TPKDS 196_ KYVEK 201_ LEALF 206_ PDLPK 211_ RNDIF 216_ DSLQK 221_ AKFDV 226_ SGLTT 231_ EQMLR 236_ KDQKT 241_ IYRQG 246_ VKVAI 251_ SAIYM 256_ DLEAF 261_ LQRSN 266_ LLADL 271_ HAFCQ 276_ AHSYD 281_ VLVAM 286_ TIFFN 291_ THNEP 296_ VRQLA 301_ IFCPH 306_ VALQT 311_ TICEV 316_ LERSH 321_ SPPLK 326_ LTPAS 331_ STHPN 336_ LHAYL 341_ QGNTQ 346_ VSRKK 351_ LLPLL 356_ QEALS 361_ AYFDS 366_ MKIPS 371_ GQPET 376_ ADVSR 381_ EQVDK 386_ ELDRA 391_ SNSLI 396_ SGLSQ 401_ DEEDP 406_ PLPPT 411_ PMNSL 416_ VDECP 421_ LDQGL 426_ PKLSA 431_ EAVFE 436_ KCSQI 441_ SLSQS 446_TTASL
1: Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, migration and differentiation, and acts as a negative regulator of NME1. Plays a role in the regulation of neurogenesis (PubMed:28334956). Involved in the regulation of microtubule polymerization (PubMed:28334956)