Actin-histidine N-methyltransferase (EC 2.1.1.85) (Protein-L-histidine N-tele-methyltransferase) (SET domain-containing protein 3) (hSETD3)
1_MGKKS 6_ RVKTQ 11_ KSGTG 16_ ATATV 21_ SPKEI 26_ LNLTS 31_ ELLQK 36_ CSSPA 41_ PGPGK 46_ EWEEY 51_ VQIRT 56_ LVEKI 61_ RKKQK 66_ GLSVT 71_ FDGKR 76_ EDYFP 81_ DLMKW 86_ ASENG 91_ ASVEG 96_ FEMVN 101_ FKEEG 106_ FGLRA 111_ TRDIK 116_ AEELF 121_ LWVPR 126_ KLLMT 131_ VESAK 136_ NSVLG 141_ PLYSQ 146_ DRILQ 151_ AMGNI 156_ ALAFH 161_ LLCER 166_ ASPNS 171_ FWQPY 176_ IQTLP 181_ SEYDT 186_ PLYFE 191_ EDEVR 196_ YLQST 201_ QAIHD 206_ VFSQY 211_ KNTAR 216_ QYAYF 221_ YKVIQ 226_ THPHA 231_ NKLPL 236_ KDSFT 241_ YEDYR 246_ WAVSS 251_ VMTRQ 256_ NQIPT 261_ EDGSR 266_ VTLAL 271_ IPLWD 276_ MCNHT 281_ NGLIT 286_ TGYNL 291_ EDDRC 296_ ECVAL 301_ QDFRA 306_ GEQIY 311_ IFYGT 316_ RSNAE 321_ FVIHS 326_ GFFFD 331_ NNSHD 336_ RVKIK 341_ LGVSK 346_ SDRLY 351_ AMKAE 356_ VLARA 361_ GIPTS 366_ SVFAL 371_ HFTEP 376_ PISAQ 381_ LLAFL 386_ RVFCM 391_ TEEEL 396_ KEHLL 401_ GDSAI 406_ DRIFT 411_ LGNSE 416_ FPVSW 421_ DNEVK 426_ LWTFL 431_ EDRAS 436_ LLLKT 441_ YKTTI 446_ EEDKS 451_ VLKNH 456_ DLSVR 461_ AKMAI 466_ KLRLG 471_ EKEIL 476_ EKAVK 481_ SAAVN 486_ REYYR 491_ QQMEE 496_ KAPLP 501_ KYEES 506_ NLGLL 511_ ESSVG 516_ DSRLP 521_ LVLRN 526_ LEEEA 531_ GVQDA 536_ LNIRE 541_ AISKA 546_ KATEN 551_ GLVNG 556_ ENSIP 561_ NGTRS 566_ ENESL 571_ NQESK 576_ RAVED 581_ AKGSS 586_SDSTA
1: Protein-histidine N-methyltransferase that specifically mediates 3-methylhistidine (tele-methylhistidine) methylation of actin at 'His-73' (PubMed:30526847, PubMed:30626964, PubMed:30785395, PubMed:31388018, PubMed:31993215). Histidine methylation of actin is required for smooth muscle contraction of the laboring uterus during delivery (PubMed:30626964). Does not have protein-lysine N-methyltransferase activity and probably only catalyzes histidine methylation of actin (PubMed:30626964, PubMed:30785395, PubMed:31388018)