Threonylcarbamoyl-AMP synthase (EC 2.7.7.87) (Dopamine receptor-interacting protein 3) (Ischemia/reperfusion-inducible protein homolog) (hIRIP)
1_MSPAR 6_ RCRGM 11_ RAAVA 16_ ASVGL 21_ SEGPA 26_ GSRSG 31_ RLFRP 36_ PSPAP 41_ AAPGA 46_ RLLRL 51_ PGSGA 56_ VQAAS 61_ PERAG 66_ WTEAL 71_ RAAVA 76_ ELRAG 81_ AVVAV 86_ PTDTL 91_ YGLAC 96_ AASCS 101_ AALRA 106_ VYRLK 111_ GRSEA 116_ KPLAV 121_ CLGRV 126_ ADVYR 131_ YCRVR 136_ VPEGL 141_ LKDLL 146_ PGPVT 151_ LVMER 156_ SEELN 161_ KDLNP 166_ FTPLV 171_ GIRIP 176_ DHAFM 181_ QDLAQ 186_ MFEGP 191_ LALTS 196_ ANLSS 201_ QASSL 206_ NVEEF 211_ QDLWP 216_ QLSLV 221_ IDGGQ 226_ IGDGQ 231_ SPECR 236_ LGSTV 241_ VDLSV 246_ PGKFG 251_ IIRPG 256_ CALES 261_ TTAIL 266_ QQKYG 271_LLPSH
1: Cytoplasmic and mitochondrial threonylcarbamoyl-AMP synthase required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (PubMed:29760464, PubMed:31481669, PubMed:34545459). Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate (PubMed:29760464). Participates in t(6)A37 formation in cytoplasmic and mitochondrial tRNAs (PubMed:29760464). May regulate the activity of some transporters (By similarity)