Suppressor APC domain-containing protein 2 (Tumor specificity and mitosis phase-dependent expression protein) (TS/MDEP) (p42.3)
1_MAGAA 6_ MAERG 11_ RVPPP 16_ APAPS 21_ TEGLP 26_ RAFLQ 31_ SLRTL 36_ FDILD 41_ DRRRG 46_ CVHLR 51_ EIESR 56_ WQGTD 61_ ARELP 66_ RGVLE 71_ GLRQV 76_ APASG 81_ YLTFE 86_ RFVAG 91_ LRTSL 96_ LSADG 101_ GPRDP 106_ TRAPA 111_ RPGDQ 116_ PPPPP 121_ QRLVF 126_ APADE 131_ PRTVL 136_ ERKPL 141_ PLGVR 146_ APLAG 151_ PSAAA 156_ RSPEQ 161_ LCAPA 166_ EAAPC 171_ PAEPE 176_ RSQSA 181_ ALEPS 186_ SSADA 191_ GAVAC 196_ RALEA 201_ DSGDA 206_ RRAPR 211_ ARGER 216_ RRHTI 221_ ASGVD 226_ CGLLK 231_ QMKEL 236_ EQEKE 241_ VLLQG 246_ LEMMA 251_ RGRDW 256_ YQQQL 261_ QRVQE 266_ RQRRL 271_ GQSRA 276_ SADFG 281_ AAGSP 286_ RPLGR 291_ LLPKV 296_ QEVAR 301_ CLGEL 306_ LAAAC 311_ ASRAL 316_ PPSSS 321_ GPPCP 326_ ALTST 331_ SPPVW 336_ QQQTI 341_ LMLKE 346_ QNRLL 351_ TQEVT 356_ EKSER 361_ ITQLE 366_ QEKSA 371_ LIKQL 376_ FEARA 381_ LSQQD 386_GGPLD
1: Plays a role in planar mitotic spindle orientation in retinal progenitor cells (RPCs) and promotes the production of symmetric terminal divisions (By similarity). Negatively regulates the mitotic apical cortex localization of GPSM2 (PubMed:26766442). Involved also in positive regulation of cell proliferation and tumor cell growth (PubMed:23576022, PubMed:23704824)